452 :618.19-006.6-003.2-079:612.148.933 (045) ., ., ., . « » » - http://www.famous-scientists.ru - , (II ). , , - , , , , , , . ( ), - - , . [3, 5, , 6]. , , , , – , - , , , , , - [1, 2, 9]. - , - , . , , [8, 11, 13, 14]. , - , - , , , , , - - , . [4, 7, 10, 12]. , - - , 12, 2007 - 453 - , ( – ) - . 30 (10,0%). II ( . - ), 2004 . 2006 . 30 . : ( ( – 3 - (3,3%) , - ), ), II - , , : ( FAC – ), - FAC – , , ( ) . . ( ( - ). ) ( ( ), « ), - (IIB ) , - , - . 1). . - ». - ( <0,001), «SYSMEX K – ( <0,001) - , , - 1000». , 1: ( ( ( ( ), ), ) - . - , , ( >0,05). ). , - , , , - ( >0,05). : – 26 (86,7%) ; ( <0,01) 12, 2007 ( <0,01). 454 1. (II ) ( 1 II 1 1 : - ) ( ) M+m P M+m P 2,94+0,112 5,12+0,121 4,97+0,072 5,26+0,135 7,26+0,314 <0,001 <0,001 <0,001 <0,001 1,40+0,152 4,76+0,021 4,56+0,085 4,57+0,305 7,13+0,278 <0,001 <0,001 <0,001 <0,001 – n = 30 – . (II - )- : . ( .1). ( <0,001), - , , - , . , , ( <0,05), ( <0,01). , - ( <0,001), ( <0,001), - - 1 . <0,05) - - , <0,001), <0,05), ( <0,001). ( <0,01), ( ( <0,001). , - - , .1). <0,05), , ( <0,01). - ( >0,05), . , - , , . ( <0,001), ( <0,001). , ( <0,01), ( <0,001); ( <0,01), ( <0,001), - , , 12, 2007 . 455 , - , : - , . , - , - . 1. - , : , <0,001) - ( <0,001) ( .1). (II ) . 2. , ( <0,001), , - ( <0,001). , - , , , ( <0,001) - . <0,001). - ( <0,001), ( <0,001), ( <0,001), ( <0,001). <0,01), . - 3. , , , - - (II ) , , , , SH- . 4. , – , - , , . - , , , , - , « . , , » . - . : 1. . 12, 2007 - 456 / . . // .-1998.- 6.- .35 2. . // .48-53 3. . , , . . . - // 9. , 2006.- 3.- 2003.- .: , 1997.-254 . . // 10.-38-41. 10. . // 34. . : ( ., 1999. - . 66-72 ., ., - .- , .- - 2002 - .3 11. ., ) // 1 - .21-28 ., . . . . , . ., 1997.- . / , . , , . . . 287 . // .-2005.- 7.- .24 12. ., . // ..- 2000.- . 360 13. Ludwig H., van Belle S., BarrettLee P. Et al. The European Cancer Anaemia Survey (ECAS): the first large, multinational, prospective survey defining the prevalence, incidence, and treatment of anemia in cancer patients. Eur J Cancer 2004; 40:2293-307 14. Peters-Engl C., Cassic P., Schmidt I. et al. Impact of haemoglobin levels during adjuvant chemotherapy on the survival of patients with primary breast cancer. Acta Oncol 2005; 44:129-33. .- 6. . // .- , 2004 – 332 . 7. (ESMO)/ . . , ; - , . .: , 2006.-128 . 8. ., - ., 1995. - 10 . 5. - ., . - ON THE IMPORTANCE OF ACTIVATION OF LIPOPEROXIDATION PROCESSES IN MECHANISMS OF DEVELOPMENT OF CYTOTOXIC EFFECTS OF POLYCHEMOTHERAPY AND RADIOTHERAPY IN PATIENTS WITH BREAST CANCER Barsukov V.Yu., Chesnokova N.P., Plokhov V.N., Seleznyova T.D. Saratov state medical university of Roszdrav, chair of pathological physiology Results of study of activation of lipoperoxidation processes, insufficiency of antiradical cellular defense in patients with nodal breast cancer (IIB stage) are presented. Complex breast cancer treatment which included neoadjuvant polychemotherapy, surgical treatment, and radiotherapy resulted in advance of free radical blood cells disorganisation, progression of leucopenia, thrombocytopenia, lymphopenia, and anemia as well as in marked manifestation of cytolisis and autointoxication. 12, 2007