ЭКСПРЕССИЯ НЕЙРОПЕПТИДОВ В ЗВЕЗДЧАТОМ ГАНГЛИИ

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616.127-005.4-036.11-02:611.83
03.03.04 –
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2016
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03.18.03
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9. Alteration of vasoactive intestinal polypeptide, substance P and
neuropeptide Y expression in the human thymus after chronic thyroiditis /
V. Roudenok, A. Nikitski, A. Sokal, A. Hancharov, A. Nerovnya, O. Saet,
T. Hrachukha, W. Kuehnel // Global Strategic Center for Radiation Health Risk
Control : proceeding 6-th Int. Sympos. Nagasaki University Global COE Program. –
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SUMMARY
Saet Olga Samuilovna
Expression of neuropeptides in human stellate ganglia in normal conditions
and in case of acute myocardial ischemia
Key words: stellate ganglion, neuropeptides, expression, acute myocardial
infarction.
Object of research: autopsy material of human stellate ganglia in the age of
45-59 years old.
Purpose of research: to identify expression patterns of substance P (SP),
met-enkephalin (met-ENK) and bombesin (Bom) in normal human stellate ganglia
and after acute myocardial infarction (AMI).
Methods of research: indirect immunohistochemical, histological,
morphometrical, statistical.
Equipment used: universal photomicroscope “Axiophot” (Zeiss), light
microscope “Olympus”, automatic images system and computer processing data,
automatic cryostat microtome “Jung” (Leika).
The results and their novelty: for the first time a research of SP, met-ENK
and Bom immunoreactivity distribution in normal human stellate ganglia and after
acute myocardial infarction was conducted. It has been revealed that in normal
human stellate ganglia heterogenic population of neurons and nerve fibers
immunoreactive to SP, Met-ENK and Bom exists. Appearance of population of small
neurons immunoreactive to SP, met-ENK and Bom is a pattern of AMI. Increase of
SP, met-ENK and Bom expression following AMI reflects the role of neuropeptides
in functional regulation of cardio-vascular system.
Recommendations on application: the new data obtained can be used as
normative during medical and biological scientific research; in patho-morphological
and medico-legal diagnostics of cardio-vascular diseases accompanied by acute
myocardial ischemia; in the development of new drugs; in medical education.
Area of application: cellular biology, cytology, histology, neurochemistry,
normal and pathological anatomy, normal and pathological physiology,
pharmacology, legal medicine, cardiology, internal diseases.
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