.Ɇ. ɀɭɤɨɜɚ ȿ -ɑɍȼɋɌȼɂɌȿɅɖɇɕɏ ɇȿɃɊɈɇɈȼ ɊɈɅɖ ɄȺɉɋȺɂɐɂɇ

ɍȾɄ 616.42: 612.821.8.
ȿ.Ɇ. ɀɭɤɨɜɚ
ɊɈɅɖ ɄȺɉɋȺɂɐɂɇ-ɑɍȼɋɌȼɂɌȿɅɖɇɕɏ ɇȿɃɊɈɇɈȼ
ȼ ɊȿȽɍɅəɐɂɂ ȽɈɊɆɈɇɋɂɇɌȿɁɂɊɍɘɓȿɃ ȺɄɌɂȼɇɈɋɌɂ
ɗɉɂɌȿɅɂɈɐɂɌɈȼ ɌɂɆɍɋȺ ɄɊɕɋ
Ƚɍ ɇɂɂ ɮɢɡɢɨɥɨɝɢɢ ɋɈ ɊȺɆɇ, ɇɨɜɨɫɢɛɢɪɫɤ
ɂɫɫɥɟɞɨɜɚɥɢ ɜɥɢɹɧɢɟ ɮɚɪɦɚɤɨɥɨɝɢɱɟɫɤɨɣ ɛɥɨɤɚɞɵ ɤɚɩɫɚɢɰɢɧ-ɱɭɜɫɬɜɢɬɟɥɶɧɵɯ ɧɟɣɪɨɧɨɜ (Ʉɑɇ) ɧɚ ɮɭɧɤɰɢɨɧɚɥɶɧɭɸ ɚɤɬɢɜɧɨɫɬɶ ɷɩɢɬɟɥɢɚɥɶɧɵɯ ɤɥɟɬɨɤ ɬɢɦɭɫɚ. ȼ ɩɟɪɜɭɸ ɧɟɞɟɥɸ ɞɟɣɫɬɜɢɹ ɤɚɩɫɚɢɰɢɧɚ, ɧɚ ɮɨɧɟ ɜɵɛɪɨɫɚ ɧɟɣɪɨɩɟɩɬɢɞɨɜ Ʉɑɇ, ɝɢɫɬɨɯɢɦɢɱɟɫɤɢɦ ɦɟɬɨɞɨɦ ɜɵɹɜɥɟɧɨ ɭɫɢɥɟɧɢɟ ɝɨɪɦɨɧɫɢɧɬɟɡɢɪɭɸɳɟɣ ɚɤɬɢɜɧɨɫɬɢ ɷɩɢɬɟɥɢɨɰɢɬɨɜ ɬɢɦɭɫɚ.
Ȼɥɨɤɚɞɚ ɧɟɣɪɨɩɟɩɬɢɞɨɜ ɜ ɨɤɨɧɱɚɧɢɹɯ Ʉɑɇ ɩɪɢɜɨɞɢɥɚ ɤ ɢɫɬɨɳɟɧɢɸ ɫɬɪɭɤɬɭɪɧɵɯ ɪɟɡɟɪɜɨɜ ɬɢɦɭɫɚ ɢ ɫɧɢɠɟɧɢɸ ɱɢɫɥɚ ɚɤɬɢɜɧɵɯ ɬɢɦɢɱɟɫɤɢɯ ɷɩɢɬɟɥɢɨɰɢɬɨɜ. ȼɨ ɜɫɟ ɫɪɨɤɢ ɷɤɫɩɟɪɢɦɟɧɬɚ ɪɨɫɥɨ ɱɢɫɥɨ ɚɥɶɞɟɝɢɞɮɭɤɫɢɧɩɨɥɨɠɢɬɟɥɶɧɵɯ ɦɚɤɪɨɮɚɝɨɜ ɜ ɫɭɛɤɚɩɫɭɥɹɪɧɨɣ
ɡɨɧɟ ɬɢɦɭɫɚ, ɱɬɨ ɫɜɢɞɟɬɟɥɶɫɬɜɭɟɬ ɨ ɪɚɡɜɢɬɢɢ ɡɚɳɢɬɧɨɣ ɪɟɚɤɰɢɢ — ɧɟɣɪɨɝɟɧɧɨɝɨ ɜɨɫɩɚɥɟɧɢɹ. Ɉɬɦɟɱɟɧɨ ɫɯɨɞɫɬɜɨ ɪɟɚɤɰɢɢ ɷɩɢɬɟɥɢɨɰɢɬɨɜ ɬɢɦɭɫɚ ɩɪɢ ɮɚɪɦɚɤɨɥɨɝɢɱɟɫɤɨɣ ɞɟɚɮɮɟɪɟɧɬɚɰɢɢ, ɢɦɦɭɧɢɡɚɰɢɢ, ɫɬɚɪɟɧɢɢ ɢ ɞɟɣɫɬɜɢɢ ɯɪɨɧɢɱɟɫɤɨɝɨ ɫɬɪɟɫɫɚ.
Ʉɥɸɱɟɜɵɟ ɫɥɨɜɚ: ɬɢɦɢɱɟɫɤɢɟ ɷɩɢɬɟɥɢɨɰɢɬɵ, ɝɨɪɦɨɧɚɥɶɧɚɹ ɚɤɬɢɜɧɨɫɬɶ, ɧɟɣɪɨɩɟɩɬɢɞɵ,
ɤɚɩɫɚɢɰɢɧ-ɱɭɜɫɬɜɢɬɟɥɶɧɵɟ ɧɟɣɪɨɧɵ, ɤɚɩɫɚɢɰɢɧ.
Ɍɢɦɭɫ — ɷɬɨ ɧɟ ɬɨɥɶɤɨ ɰɟɧɬɪɚɥɶɧɵɣ ɨɪɝɚɧ
ɢɦɦɭɧɨɝɟɧɟɡɚ, ɧɨ ɢ ɷɧɞɨɤɪɢɧɧɚɹ ɠɟɥɟɡɚ. ȿɝɨ
ɷɧɞɨɤɪɢɧɧɚɹ ɮɭɧɤɰɢɹ ɫɜɹɡɚɧɚ ɫ ɩɪɨɞɭɤɰɢɟɣ
ɝɨɪɦɨɧɨɜ ɷɩɢɬɟɥɢɚɥɶɧɵɦɢ ɤɥɟɬɤɚɦɢ [1]. ɗɩɢɬɟɥɢɨɰɢɬɵ ɫɨɫɬɚɜɥɹɸɬ ɨɩɨɪɧɭɸ ɫɬɪɭɤɬɭɪɭ ɠɟɥɟɡɵ ɢ ɩɪɨɞɭɰɢɪɭɸɬ ɝɨɪɦɨɧɵ: ɫɜɟɬɥɵɟ ɫɭɛɤɚɩɫɭɥɹɪɧɵɟ — ɦɟɫɬɧɨɞɟɣɫɬɜɭɸɳɢɟ (ɬɢɦɨɡɢɧɵ,
ɬɢɦɨɩɨɷɬɢɧ), ɚ ɬɟɦɧɵɟ ɜɧɭɬɪɢɤɨɪɬɢɤɚɥɶɧɵɟ
ɢ ɦɟɞɭɥɥɹɪɧɵɟ — ɞɢɫɬɚɧɬɧɨɞɟɣɫɬɜɭɸɳɢɟ (ɬɢɦɭɥɢɧ), ɫɟɤɪɟɬɢɪɭɟɦɵɟ ɜ ɤɪɨɜɶ. Ⱦɟɧɞɪɢɬɧɵɟ
ɨɤɨɧɱɚɧɢɹ ɩɫɟɜɞɨɭɧɢɩɨɥɹɪɧɵɯ ɧɟɣɪɨɩɟɩɬɢɞɫɨɞɟɪɠɚɳɢɯ ɚɮɮɟɪɟɧɬɧɵɯ ɧɟɣɪɨɧɨɜ ɫɩɢɧɚɥɶɧɵɯ ɝɚɧɝɥɢɟɜ C2-C4 ɨɛɢɥɶɧɨ ɢɧɧɟɪɜɢɪɭɸɬ ɬɢɦɭɫ [2]. ȼ ɡɨɧɟ ɥɨɤɚɥɢɡɚɰɢɢ ɩɟɪɢɮɟɪɢɱɟɫɤɢɯ
ɫɟɧɫɨɪɧɵɯ ɨɬɪɨɫɬɤɨɜ ɨɬɦɟɱɟɧɚ ɜɵɫɨɤɚɹ ɢɦɦɭɧɨɪɟɚɤɬɢɜɧɨɫɬɶ ɤ ɜɟɳɟɫɬɜɭ P [3] ɢ ɡɧɚɱɢɬɟɥɶɧɚɹ ɩɥɨɬɧɨɫɬɶ NK-1 ɪɟɰɟɩɬɨɪɨɜ ɤ ɧɟɣɪɨɩɟɩɬɢɞɚɦ [8].
ɉɟɪɜɢɱɧɵɟ ɚɮɮɟɪɟɧɬɧɵɟ ɧɟɣɪɨɧɵ, ɫɨɝɥɚɫɧɨ
ɫɨɜɪɟɦɟɧɧɵɦ ɩɪɟɞɫɬɚɜɥɟɧɢɹɦ, ɧɟ ɬɨɥɶɤɨ ɩɟɪɟɞɚɸɬ ɢɧɮɨɪɦɚɰɢɸ ɜ ɐɇɋ, ɧɨ ɢ ɨɤɚɡɵɜɚɸɬ ɥɨɤɚɥɶɧɨɟ ɞɟɣɫɬɜɢɟ ɧɚ ɩɟɪɢɮɟɪɢɢ. ɗɬɨ — ɧɨɜɵɣ
ɚɫɩɟɤɬ ɢɡɭɱɟɧɢɹ ɮɢɡɢɨɥɨɝɢɱɟɫɤɢɯ ɦɟɯɚɧɢɡɦɨɜ
ɪɟɝɭɥɹɰɢɢ ɝɨɦɟɨɫɬɚɡɚ. ɂɯ ɪɨɥɶ ɜ ɪɟɝɭɥɹɰɢɢ
ɫɬɪɭɤɬɭɪɧɨɣ ɨɪɝɚɧɢɡɚɰɢɢ ɢ ɮɭɧɤɰɢɨɧɚɥɶɧɨɣ
ɚɤɬɢɜɧɨɫɬɢ ɥɢɦɮɨɢɞɧɵɯ ɨɪɝɚɧɨɜ ɧɟ ɢɫɫɥɟɞɨɜɚɧɚ. ɂɦɟɸɬɫɹ ɥɢɲɶ ɨɬɞɟɥɶɧɵɟ ɫɜɟɞɟɧɢɹ ɨ ɜɥɢɹɧɢɢ ɧɟɨɧɚɬɚɥɶɧɨɝɨ ɜɜɟɞɟɧɢɹ ɤɚɩɫɚɢɰɢɧɚ ɧɚ
ɢɦɦɭɧɧɵɣ ɨɬɜɟɬ ɥɢɦɮɨɰɢɬɨɜ ɤɪɨɜɢ ɭ ɧɨɜɨɪɨɠɞɟɧɧɵɯ ɢ ɭ ɜɡɪɨɫɥɵɯ ɤɪɵɫ, ɨ ɫɧɢɠɟɧɢɢ ɜ ɷɬɢɯ
138
ɭɫɥɨɜɢɹɯ ɰɢɬɨɬɨɤɫɢɱɟɫɤɨɣ ɚɤɬɢɜɧɨɫɬɢ ɧɚɬɭɪɚɥɶɧɵɯ ɤɢɥɥɟɪɨɜ, ɧɚɪɭɲɟɧɢɢ ɨɬɞɟɥɶɧɵɯ ɷɬɚɩɨɜ ɞɢɮɮɟɪɟɧɰɢɪɨɜɤɢ ɬɢɦɨɰɢɬɨɜ [5]. Ɉɞɧɚɤɨ
ɧɟɨɧɚɬɚɥɶɧɨɟ ɜɜɟɞɟɧɢɟ ɤɚɩɫɚɢɰɢɧɚ ɩɪɢɜɨɞɢɬ
ɤ ɩɨɥɧɨɣ ɞɟɝɟɧɟɪɚɰɢɢ ɫɟɧɫɨɪɧɵɯ ɨɤɨɧɱɚɧɢɣ,
ɱɬɨ ɤɨɦɩɟɧɫɢɪɭɟɬɫɹ ɡɚ ɫɱɟɬ ɭɫɢɥɟɧɢɹ ɮɭɧɤɰɢɢ
ɚɞɪɟɧɟɪɝɢɱɟɫɤɢɯ ɢ ɯɨɥɢɧɟɪɝɢɱɟɫɤɢɯ ɧɟɣɪɨɧɨɜ.
Ɍɚɤɚɹ ɦɨɞɟɥɶ ɧɟɩɪɢɝɨɞɧɚ ɞɥɹ ɢɫɫɥɟɞɨɜɚɧɢɣ
ɮɢɡɢɨɥɨɝɢɱɟɫɤɨɣ ɪɨɥɢ Ʉɑɇ. ȼ ɫɜɹɡɢ ɫ ɷɬɢɦ,
ɩɪɨɜɨɞɢɥɚɫɶ ɪɚɛɨɬɚ ɫ ɰɟɥɶɸ ɜɵɹɜɥɟɧɢɹ ɢɡɦɟɧɟɧɢɹ ɮɭɧɤɰɢɨɧɚɥɶɧɨɣ ɚɤɬɢɜɧɨɫɬɢ ɷɩɢɬɟɥɢɨɰɢɬɨɜ ɬɢɦɭɫɚ ɜ ɞɢɧɚɦɢɤɟ ɩɨɫɥɟ ɜɜɟɞɟɧɢɹ ɩɨɥɨɜɨɡɪɟɥɵɦ ɤɪɵɫɚɦ ɧɟɣɪɨɬɨɤɫɢɱɟɫɤɨɣ ɞɨɡɵ ɤɚɩɫɚɢɰɢɧɚ, ɩɨɡɜɨɥɹɸɳɟɣ ɜɪɟɦɟɧɧɨ «ɜɵɤɥɸɱɚɬɶ»
ɚɮɮɟɪɟɧɬɧɭɸ ɢɦɩɭɥɶɫɚɰɢɸ.
Ɇɚɬɟɪɢɚɥɵ ɢ ɦɟɬɨɞɵ
ɗɤɫɩɟɪɢɦɟɧɬɵ ɜɵɩɨɥɧɟɧɵ ɧɚ 40 ɩɨɥɨɜɨɡɪɟɥɵɯ ɫɚɦɰɚɯ ɤɪɵɫ ɥɢɧɢɢ ȼɢɫɬɚɪ ɨɞɧɨɝɨ ɜɨɡɪɚɫɬɚ, ɦɚɫɫɨɣ 150-250 ɝ. (ɩɢɬɨɦɧɢɤ ɊȺɆɇ «ɋɬɨɥɛɨɜɚɹ»). ɀɢɜɨɬɧɵɟ ɫɨɞɟɪɠɚɥɢɫɶ ɜ ɫɬɚɧɞɚɪɬɧɵɯ
ɭɫɥɨɜɢɹɯ ɜɢɜɚɪɢɹ ɩɪɢ ɟɫɬɟɫɬɜɟɧɧɨɦ ɨɫɜɟɳɟɧɢɢ
ɢ ɨɛɵɱɧɨɣ ɞɢɟɬɟ. Ʉɚɩɫɚɢɰɢɧ (Sigma, ɋɒȺ, 1%
ɪɚɫɬɜɨɪ ɜ ɪɚɫɬɜɨɪɢɬɟɥɟ) ɜɜɨɞɢɥɢ ɩɨɞɤɨɠɧɨ ɩɨɞ
ɥɟɝɤɢɦ ɷɮɢɪɧɵɦ ɧɚɪɤɨɡɨɦ ɜ ɬɟɱɟɧɢɟ ɞɜɭɯ ɞɧɟɣ
ɫ ɢɧɬɟɪɜɚɥɨɦ ɜ 12 ɱɚɫɨɜ, ɱɬɨɛɵ ɭɫɬɪɚɧɢɬɶ ɷɮɮɟɤɬ ɫɟɧɫɢɬɢɡɚɰɢɢ, ɜ ɞɨɡɚɯ 25, 25, 50 ɢ 50 ɦɝ
(ɫɭɦɦɚɪɧɚɹ ɧɟɣɪɨɬɨɤɫɢɱɟɫɤɚɹ ɞɨɡɚ 150 ɦɝ/ɤɝ).
ɋɨɫɬɚɜ ɪɚɫɬɜɨɪɢɬɟɥɹ ɞɥɹ ɤɚɩɫɚɢɰɢɧɚ: 10% ɷɬɢɥɨɜɵɣ ɫɩɢɪɬ, 10% Ɍɜɢɧ-80, 80% ɮɢɡɢɨɥɨɝɢɱɟɫɤɢɣ ɪɚɫɬɜɨɪ. Ʉɨɧɬɪɨɥɟɦ ɫɥɭɠɢɥɢ 10 ɠɢɜɨɬ¡fiÀÀ“Õ‹ –Œ —¿ÃÕ, ʋ 3 (125), 2007 „.
ɀɭɤɨɜɚ ȿ.Ɇ. Ɋɨɥɶ ɤɚɩɫɚɢɰɢɧ-ɱɭɜɫɬɜɢɬɟɥɶɧɵɯ ɧɟɣɪɨɧɨɜ ɜ ɪɟɝɭɥɹɰɢɢ ɝɨɪɦɨɧɫɢɧɬɟɡɢɪɭɸɳɟɣ ɚɤɬɢɜɧɨɫɬɢ
ɷɩɢɬɟɥɢɨɰɢɬɨɜ ɬɢɦɭɫɚ ɤɪɵɫ / ɫ. 138-141
ɧɵɯ, ɤɨɬɨɪɵɦ ɜɜɨɞɢɥɢ ɬɨɥɶɤɨ ɪɚɫɬɜɨɪɢɬɟɥɶ ɞɥɹ
ɤɚɩɫɚɢɰɢɧɚ. Ⱦɥɹ ɢɫɫɥɟɞɨɜɚɧɢɹ ɦɟɬɨɞɨɦ ɫɜɟɬɨɜɨɣ ɦɢɤɪɨɫɤɨɩɢɢ ɤɭɫɨɱɤɢ ɬɢɦɭɫɚ ɮɢɤɫɢɪɨɜɚɥɢ
ɜ ɤɢɫɥɨɦ ɮɢɤɫɚɬɨɪɟ Ɍɟɥɟɫɧɢɰɤɨɝɨ ɢ ɜ ɠɢɞɤɨɫɬɢ
Ȼɭɟɧɚ, ɡɚɥɢɜɚɥɢ ɜ ɩɚɪɚɮɢɧ. ɋɪɟɡɵ ɨɤɪɚɲɢɜɚɥɢ
ɞɥɹ ɨɛɡɨɪɧɨɝɨ ɩɪɨɫɦɨɬɪɚ ɝɟɦɚɬɨɤɫɢɥɢɧɨɦɷɨɡɢɧɨɦ, ɞɥɹ ɰɢɬɨɥɨɝɢɱɟɫɤɢɯ ɢɫɫɥɟɞɨɜɚɧɢɣ —
ɚɡɭɪ ȼ-ɷɨɡɢɧɨɦ Y ɩɨ ɇɨɯɬ–Ɇɚɤɫɢɦɨɜɭ. Ⱦɥɹ ɢɫɫɥɟɞɨɜɚɧɢɹ ɚɤɬɢɜɧɨɫɬɢ ɷɩɢɬɟɥɢɨɰɢɬɨɜ ɬɢɦɭɫɚ
ɩɪɨɜɨɞɢɥɢ ɨɤɪɚɫɤɭ ɟɝɨ ɫɪɟɡɨɜ ɚɥɶɞɟɝɢɞɮɭɤɫɢɧɨɦ ɫ ɞɨɤɪɚɫɤɨɣ ɫɦɟɫɶɸ Ƚɟɥɶɦɢ ɩɨ ɦɟɬɨɞɭ Ƚɵɛɚ–Ⱦɵɛɚɧɚ. Ɇɟɬɨɞ ɢɡɛɢɪɚɬɟɥɶɧɨ ɜɵɹɜɥɹɟɬ ɷɩɢɬɟɥɢɨɰɢɬɵ, ɦɚɤɪɨɮɚɝɢ ɤɨɪɤɨɜɨɣ ɡɨɧɵ, ɬɤɚɧɟɜɵɟ
ɛɚɡɨɮɢɥɵ [6]. ȼɵɫɨɤɚɹ ɰɜɟɬɨɜɚɹ ɤɨɧɬɪɚɫɬɧɨɫɬɶ
ɦɟɬɨɞɢɤɢ ɩɨɡɜɨɥɹɟɬ ɞɚɜɚɬɶ ɰɢɬɨɮɢɡɢɨɥɨɝɢɱɟɫɤɭɸ ɯɚɪɚɤɬɟɪɢɫɬɢɤɭ ɤɥɟɬɨɱɧɵɯ ɷɥɟɦɟɧɬɨɜ
ɢ ɫɭɞɢɬɶ ɨ ɫɬɟɩɟɧɢ ɢɯ ɮɭɧɤɰɢɨɧɚɥɶɧɨɣ ɚɤɬɢɜɧɨɫɬɢ. Ɋɚɛɨɬɚ ɜɵɩɨɥɧɟɧɚ ɜ ɫɨɨɬɜɟɬɫɬɜɢɢ ɫ ɝɭɦɚɧɧɵɦɢ ɧɨɪɦɚɦɢ, ɩɪɟɞɭɫɦɨɬɪɟɧɧɵɦɢ ɦɟɠɞɭɧɚɪɨɞɧɨɣ ɚɫɫɨɰɢɚɰɢɟɣ ɢɫɫɥɟɞɨɜɚɧɢɣ ɧɚ ɷɤɫɩɟɪɢɦɟɧɬɚɥɶɧɵɯ ɠɢɜɨɬɧɵɯ ɢ ɨɞɨɛɪɟɧɚ ɗɬɢɱɟɫɤɢɦ ɤɨɦɢɬɟɬɨɦ Ƚɍ ɇɂɂ ɮɢɡɢɨɥɨɝɢɢ ɋɈ
ɊȺɆɇ. ɋɬɚɬɢɫɬɢɱɟɫɤɭɸ ɨɛɪɚɛɨɬɤɭ ɩɨɥɭɱɟɧɧɵɯ
ɞɚɧɧɵɯ ɩɪɨɢɡɜɨɞɢɥɢ ɫ ɩɨɦɨɳɶɸ ɫɬɚɧɞɚɪɬɧɨɣ
ɤɨɦɩɶɸɬɟɪɧɨɣ ɩɪɨɝɪɚɦɦɵ. Ɉɰɟɧɤɭ ɞɨɫɬɨɜɟɪɧɨɫɬɢ ɪɟɡɭɥɶɬɚɬɨɜ ɷɤɫɩɟɪɢɦɟɧɬɨɜ ɩɪɨɜɨɞɢɥɢ ɩɨ
t-ɤɪɢɬɟɪɢɸ ɋɬɶɸɞɟɧɬɚ.
Ɋɟɡɭɥɶɬɚɬɵ ɢ ɢɯ ɨɛɫɭɠɞɟɧɢɟ
Ɇɨɪɮɨɦɟɬɪɢɱɟɫɤɢɦɢ ɦɟɬɨɞɚɦɢ ɧɟ ɜɵɹɜɥɟɧɨ
ɞɨɫɬɨɜɟɪɧɵɯ ɤɨɥɢɱɟɫɬɜɟɧɧɵɯ ɢɡɦɟɧɟɧɢɣ ɷɩɢɬɟɥɢɚɥɶɧɨɝɨ ɤɨɦɩɨɧɟɧɬɚ ɬɢɦɭɫɚ ɩɨɫɥɟ ɤɚɩɫɚɢɰɢɧɨɜɨɣ ɨɛɪɚɛɨɬɤɢ, ɨɞɧɚɤɨ ɜɢɡɭɚɥɶɧɨ ɨɬɦɟɱɚɥɢɫɶ ɩɪɢɡɧɚɤɢ ɟɝɨ ɜɨɡɛɭɠɞɟɧɢɹ. ɗɬɨ ɫɨɩɪɨɜɨɠɞɚɥɨɫɶ ɩɨɬɟɪɟɣ ɱɟɬɤɨ ɜɵɪɚɠɟɧɧɨɣ ɞɨɥɶɱɚɬɨɫɬɢ
ɝɢɫɬɨɥɨɝɢɱɟɫɤɢɯ ɫɪɟɡɨɜ ɬɢɦɭɫɚ.
ɇɚ ɨɤɪɚɲɟɧɧɵɯ ɚɥɶɞɟɝɢɞɮɭɤɫɢɧɨɦ ɩɨ ȽɚɛɚȾɵɛɚɧɭ ɫɪɟɡɚɯ ɬɢɦɭɫɚ ɭ ɨɩɵɬɧɵɯ ɤɪɵɫ ɱɟɪɟɡ
ɧɟɞɟɥɸ ɞɟɣɫɬɜɢɹ ɤɚɩɫɚɢɰɢɧɚ ɱɚɫɬɨ ɜɫɬɪɟɱɚɥɢɫɶ
ɫɜɟɬɥɵɟ ɷɩɢɬɟɥɢɚɥɶɧɵɟ ɤɥɟɬɤɢ ɫ ɢɧɬɟɧɫɢɜɧɨ
ɨɤɪɚɲɟɧɧɵɦɢ ɜ ɮɢɨɥɟɬɨɜɵɣ ɰɜɟɬ ɩɵɥɟɜɢɞɧɵɦɢ ɜɤɥɸɱɟɧɢɹɦɢ ɜɨɤɪɭɝ ɹɞɪɚ ɢ ɦɟɥɤɢɦɢ ɜɚɤɭɨɥɹɦɢ ɜ ɰɢɬɨɩɥɚɡɦɟ. Ⱥɥɶɞɟɝɢɞɮɭɤɫɢɧɩɨɥɨɠɢɬɟɥɶɧɵɟ ɷɩɢɬɟɥɢɨɰɢɬɵ ɪɚɫɩɨɥɚɝɚɥɢɫɶ ɧɚ ɫɪɟɡɟ
ɪɹɞɨɦ ɢɥɢ ɤɨɧɬɚɤɬɢɪɨɜɚɥɢ ɞɪɭɝ ɫ ɞɪɭɝɨɦ, ɢ ɢɯ
ɤɨɥɢɱɟɫɬɜɨ ɛɵɥɨ ɜɵɲɟ ɧɨɪɦɵ (ɤɨɧɬɪɨɥɶ:
13,4±2,7 ɨɩɵɬ: 24±2,5; P < 0,01; ɪɢɫɭɧɨɤ).
ɗɬɢ ɢɡɦɟɧɟɧɢɹ ɦɨɝɭɬ ɛɵɬɶ ɪɟɡɭɥɶɬɚɬɨɦ ɭɫɢɥɟɧɢɹ ɩɪɨɰɟɫɫɨɜ ɫɢɧɬɟɡɚ ɬɢɦɢɱɟɫɤɢɯ ɝɨɪɦɨɧɨɜ
ɜ ɨɬɜɟɬ ɧɚ ɜɵɛɪɨɫ ɧɟɣɪɨɩɟɩɬɢɞɨɜ ɢɡ ɫɟɧɫɨɪɧɵɯ
ɨɤɨɧɱɚɧɢɣ ɩɨɞ ɜɥɢɹɧɢɟɦ ɤɚɩɫɚɢɰɢɧɚ. ɂɡɜɟɫɬɧɨ,
ɱɬɨ ɷɩɢɬɟɥɢɚɥɶɧɵɟ ɤɥɟɬɤɢ ɬɢɦɭɫɚ ɢɦɟɸɬ ɫɩɟɰɢɮɢɱɟɫɤɢɟ ɞɥɹ ɧɟɣɪɨɩɟɩɬɢɞɨɜ NK-1 ɢ ɜɚɧɢɥɥɨɢɞɧɵɟ ɪɟɰɟɩɬɨɪɵ [7, 8]. ȼ ɨɩɵɬɚɯ in vitro ɨɬ¡fiÀÀ“Õ‹ –Œ —¿ÃÕ, ʋ 3 (125), 2007 „.
Ɋɢɫ. ɂɡɦɟɧɟɧɢɟ ɱɢɫɥɚ ɚɥɶɞɟɝɢɞɮɭɤɫɢɧɩɨɥɨɠɢɬɟɥɶɧɵɯ
ɷɩɢɬɟɥɢɨɰɢɬɨɜ (ɗɩ ȺɎ+) ɢ ɦɚɤɪɨɮɚɝɨɜ (Ɇɮ ȺɎ+)
ɧɚ ɫɬɚɧɞɚɪɬɧɨɣ ɩɥɨɳɚɞɢ ɫɪɟɡɚ ɬɢɦɭɫɚ ɭ ɤɨɧɬɪɨɥɶɧɵɯ
ɤɪɵɫ ɢ ɜ ɪɚɡɧɵɟ ɫɪɨɤɢ ɩɨɫɥɟ ɜɜɟɞɟɧɢɹ ɤɚɩɫɚɢɰɢɧɚ
(Ʉɫ, 150 ɦɝ/ɤɝ).
* — P < 0,05; ** — P < 0,01 ɤ ɭɪɨɜɧɸ ɤɨɧɬɪɨɥɹ.
ɦɟɱɟɧɨ ɭɫɢɥɟɧɢɟ ɮɭɧɤɰɢɨɧɚɥɶɧɨɣ ɚɤɬɢɜɧɨɫɬɢ
ɷɩɢɬɟɥɢɚɥɶɧɵɯ ɤɥɟɬɨɤ ɪɚɡɧɵɯ ɨɪɝɚɧɨɜ ɩɨɫɥɟ
ɜɜɟɞɟɧɢɹ ɷɧɞɨɝɟɧɧɵɯ ɧɟɣɪɨɩɟɩɬɢɞɨɜ ɢ ɫɬɢɦɭɥɢɪɭɸɳɢɯ (ɦɚɥɵɯ) ɞɨɡ ɤɚɩɫɚɢɰɢɧɚ [14].
ȼɨ ɜɬɨɪɭɸ ɧɟɞɟɥɸ ɞɟɣɫɬɜɢɹ ɩɪɟɩɚɪɚɬɚ
ɤɨɥɢɱɟɫɬɜɨ ɷɩɢɬɟɥɢɨɰɢɬɨɜ, ɨɤɪɚɲɟɧɧɵɯ
ɚɥɶɞɟɝɢɞɮɭɤɫɢɧɨɦ, ɫɧɢɠɚɥɨɫɶ ɜ ɞɜɚ ɪɚɡɚ ɩɨ
ɫɪɚɜɧɟɧɢɸ ɫ ɤɨɧɬɪɨɥɟɦ (P < 0,05) ɢ ɜ ɬɪɢ ɪɚɡɚ
(P < 0,01) ɩɨ ɫɪɚɜɧɟɧɢɸ ɫ ɩɪɟɞɵɞɭɳɢɦ ɫɪɨɤɨɦ ɧɚɛɥɸɞɟɧɢɹ (8,1±1,5; ɪɢɫɭɧɨɤ). ɇɚɢɛɨɥɟɟ
ɡɚɦɟɬɧɨ ɫɨɤɪɚɬɢɥɨɫɶ ɱɢɫɥɨ ɨɤɪɚɲɟɧɧɵɯ ɚɥɶɞɟɝɢɞɮɭɤɫɢɧɨɦ ɤɥɟɬɨɤ ɜ ɦɨɡɝɨɜɨɦ ɜɟɳɟɫɬɜɟ ɬɢɦɭɫɚ, ɝɞɟ ɥɨɤɚɥɢɡɭɸɬɫɹ ɬɟɦɧɵɟ ɷɩɢɬɟɥɢɨɰɢɬɵ,
ɫɟɤɪɟɬɢɪɭɸɳɢɟ ɝɨɪɦɨɧ ɞɢɫɬɚɧɬɧɨɝɨ ɞɟɣɫɬɜɢɹ
— ɬɢɦɭɥɢɧ. ȼ ɷɩɢɬɟɥɢɚɥɶɧɨɣ ɫɟɬɢ ɢɦɟɥɢɫɶ
ɤɪɭɩɧɵɟ ɫɤɨɩɥɟɧɢɹ ɦɚɤɪɨɮɚɝɨɜ. ɂɡɜɟɫɬɧɨ,
ɱɬɨ ɭɦɟɧɶɲɟɧɢɟ ɱɢɫɥɚ ɚɥɶɞɟɝɢɞɮɭɤɫɢɧɩɨɥɨɠɢɬɟɥɶɧɵɯ ɷɩɢɬɟɥɢɨɰɢɬɨɜ ɫɜɢɞɟɬɟɥɶɫɬɜɭɟɬ
ɨ ɫɧɢɠɟɧɢɢ ɮɭɧɤɰɢɨɧɚɥɶɧɨɣ ɢ ɩɪɨɥɢɮɟɪɚɬɢɜɧɨɣ ɚɤɬɢɜɧɨɫɬɢ ɷɩɢɬɟɥɢɨɰɢɬɨɜ ɬɢɦɭɫɚ
[15]. ɗɮɮɟɤɬ ɫɜɹɡɚɧ, ɜɟɪɨɹɬɧɨ, ɫɨ ɫɧɢɠɟɧɢɟɦ
ɭɪɨɜɧɹ ɧɟɣɪɨɩɟɩɬɢɞɨɜ ɜɫɥɟɞɫɬɜɢɟ ɞɟɝɟɧɟɪɚɰɢɢ ɩɟɪɢɮɟɪɢɱɟɫɤɢɯ ɫɟɧɫɨɪɧɵɯ ɨɤɨɧɱɚɧɢɣ,
ɤɨɬɨɪɚɹ ɪɚɡɜɢɜɚɟɬɫɹ ɜɨ ɜɬɨɪɭɸ ɧɟɞɟɥɸ ɞɟɣɫɬɜɢɹ ɧɟɣɪɨɬɨɤɫɢɱɟɫɤɨɣ ɞɨɡɵ ɤɚɩɫɚɢɰɢɧɚ ɩɨɥɨɜɨɡɪɟɥɵɦ ɤɪɵɫɚɦ [16].
Ɉɫɥɚɛɥɟɧɢɟ ɝɨɪɦɨɧɫɢɧɬɟɡɢɪɭɸɳɟɣ ɚɤɬɢɜɧɨɫɬɢ ɷɩɢɬɟɥɢɨɰɢɬɨɜ ɬɢɦɭɫɚ ɯɚɪɚɤɬɟɪɧɵ
ɜ ɭɫɥɨɜɢɹɯ ɞɟɣɫɬɜɢɹ ɯɪɨɧɢɱɟɫɤɨɝɨ ɫɬɪɟɫɫɚ
[17], ɩɪɢ ɪɚɡɜɢɬɢɢ ɚɥɥɟɪɝɢɱɟɫɤɢɯ, ɚɭɬɨɢɦɦɭɧɧɵɯ ɩɪɨɰɟɫɫɨɜ [18] ɢ ɫɬɚɪɟɧɢɢ [19].
ɋɬɪɭɤɬɭɪɧɵɟ ɢɡɦɟɧɟɧɢɹ ɷɩɢɬɟɥɢɚɥɶɧɵɯ ɤɥɟɬɨɤ ɬɢɦɭɫɚ ɭ ɨɩɵɬɧɵɯ ɤɪɵɫ ɫɜɢɞɟɬɟɥɶɫɬɜɨɜɚɥɢ ɨ ɫɧɢɠɟɧɢɢ ɮɭɧɤɰɢɨɧɚɥɶɧɨɣ ɢ ɩɪɨɥɢɮɟɪɚɬɢɜɧɨɣ ɚɤɬɢɜɧɨɫɬɢ. Ⱥɧɚɥɨɝɢɱɧɵɟ ɹɜɥɟɧɢɹ
ɨɬɦɟɱɚɥɢɫɶ ɭ ɠɢɜɨɬɧɵɯ ɩɪɢ ɫɬɚɪɟɧɢɢ [20],
ɭ ɝɟɧɟɬɢɱɟɫɤɨɣ ɥɢɧɢɢ ɦɵɲɟɣ NZB/W ɫ ɜɪɨɠɞɟɧɧɵɦ
ɚɭɬɨɢɦɦɭɧɧɵɦ
ɤɨɧɮɥɢɤɬɨɦ,
139
ɀɭɤɨɜɚ ȿ.Ɇ. Ɋɨɥɶ ɤɚɩɫɚɢɰɢɧ-ɱɭɜɫɬɜɢɬɟɥɶɧɵɯ ɧɟɣɪɨɧɨɜ ɜ ɪɟɝɭɥɹɰɢɢ ɝɨɪɦɨɧɫɢɧɬɟɡɢɪɭɸɳɟɣ ɚɤɬɢɜɧɨɫɬɢ
ɷɩɢɬɟɥɢɨɰɢɬɨɜ ɬɢɦɭɫɚ ɤɪɵɫ / ɫ. 138-141
ɭ ɛɨɥɶɧɵɯ ɫ ɪɟɜɦɚɬɢɱɟɫɤɢɦɢ ɚɭɬɨɢɦɦɭɧɧɵɦɢ ɢ ɯɪɨɧɢɱɟɫɤɢɦɢ ɜɨɫɩɚɥɢɬɟɥɶɧɵɦɢ ɡɚɛɨɥɟɜɚɧɢɹɦɢ [21].
ɇɚ 21 ɞɟɧɶ ɩɨɫɥɟ ɜɜɟɞɟɧɢɹ ɤɚɩɫɚɢɰɢɧɚ ɝɨɪɦɨɧɫɢɧɬɟɡɢɪɭɸɳɚɹ ɚɤɬɢɜɧɨɫɬɶ ɷɩɢɬɟɥɢɨɰɢɬɨɜ
ɬɢɦɭɫɚ ɜɨɫɫɬɚɧɚɜɥɢɜɚɥɚɫɶ, ɤɨɥɢɱɟɫɬɜɨ ɚɥɶɞɟɝɢɞɮɭɤɫɢɧɩɨɥɨɠɢɬɟɥɶɧɵɯ ɷɩɬɟɥɢɨɰɢɬɨɜ ɧɟ ɨɬɥɢɱɚɥɨɫɶ ɨɬ ɭɪɨɜɧɹ ɤɨɧɬɪɨɥɹ (10,6±1,8;
P < 0,01; ɪɢɫɭɧɨɤ).
ȼɨ ɜɫɟ ɫɪɨɤɢ ɞɟɣɫɬɜɢɹ ɤɚɩɫɚɢɰɢɧɚ ɧɚ ɫɪɟɡɚɯ
ɬɢɦɭɫɚ, ɨɤɪɚɲɟɧɧɵɯ ɩɨ ɦɟɬɨɞɭ Ƚɚɛɚ–Ⱦɵɛɚɧɚ,
ɭɜɟɥɢɱɢɥɨɫɶ ɤɨɥɢɱɟɫɬɜɨ ɚɥɶɞɟɝɢɞɮɭɤɫɢɧɩɨɥɨɠɢɬɟɥɶɧɵɯ ɝɪɚɧɭɥ ɜɧɭɬɪɢ ɦɚɤɪɨɮɚɝɨɜ ɤɨɪɵ
ɢ ɫɭɛɤɚɩɫɭɥɹɪɧɨɣ ɡɨɧɵ. Ⱥɥɶɞɟɝɢɞɮɭɤɫɢɧɨɮɢɥɢɹ ɫɜɢɞɟɬɟɥɶɫɬɜɭɟɬ ɨɛ ɭɫɢɥɟɧɢɢ ɮɚɝɨɰɢɬɚɪɧɨɣ
ɚɤɬɢɜɧɨɫɬɢ. ȼɨɡɦɨɠɧɨ, ɩɪɢ ɷɬɨɦ ɭɫɢɥɢɜɚɸɬɫɹ
ɢ ɞɪɭɝɢɟ ɩɪɨɹɜɥɟɧɢɹ ɮɭɧɤɰɢɨɧɚɥɶɧɨɣ ɚɤɬɢɜɧɨɫɬɢ ɦɨɧɨɧɭɤɥɟɚɪɧɵɯ ɮɚɝɨɰɢɬɨɜ. ɋɨɝɥɚɫɧɨ ɞɚɧɧɵɦ ɥɢɬɟɪɚɬɭɪɵ, ɩɪɢ ɞɟɣɫɬɜɢɢ ɧɚ ɬɚɯɢɤɢɧɢɧɨɜɵɟ ɪɟɰɟɩɬɨɪɵ ɭɫɢɥɢɜɚɟɬɫɹ ɩɪɨɞɭɤɰɢɹ ɰɢɬɨɤɢɧɨɜ ɤɭɥɶɬɢɜɢɪɭɟɦɵɦɢ ɦɨɧɨɰɢɬɚɦɢ ɤɪɨɜɢ [22].
ɉɨɞ ɞɟɣɫɬɜɢɟɦ ɤɚɩɫɚɢɰɢɧɚ ɜɵɪɨɫɥɨ ɤɨɥɢɱɟɫɬɜɨ
ɚɥɶɞɟɝɢɞɮɭɤɫɢɧɩɨɥɨɠɢɬɟɥɶɧɵɯ ɦɚɤɪɨɮɚɝɨɜ ɧɚ
ɫɪɟɡɚɯ ɬɢɦɭɫɚ (ɤɨɧɬɪɨɥɶ: 6,5±1,6, ɫɟɦɶ ɫɭɬɨɤ
ɞɟɣɫɬɜɢɹ ɤɚɩɫɚɢɰɢɧɚ: 11,7±1,5; ɞɜɟ ɧɟɞɟɥɢ —
27,6±3,4, ɬɪɢ ɧɟɞɟɥɢ — 21,4±2,2, ɪɢɫɭɧɨɤ). ɗɬɨɬ
ɪɨɫɬ ɦɨɠɟɬ ɜɵɡɵɜɚɬɶ ɧɚɪɭɲɟɧɢɟ ɷɜɚɤɭɚɰɢɢ
ɝɨɪɦɨɧɨɜ ɬɢɦɭɫɚ.
ɂɧɬɟɧɫɢɜɧɨ ɨɤɪɚɲɟɧɧɵɟ ɚɥɶɞɟɝɢɞɮɭɤɫɢɧɨɦ ɦɚɤɪɨɮɚɝɢ ɭ ɨɛɪɚɛɨɬɚɧɧɵɯ ɤɚɩɫɚɢɰɢɧɨɦ
ɤɪɵɫ ɜ ɨɛɥɚɫɬɢ ɤɨɪɬɢɤɨ-ɦɟɞɭɥɥɹɪɧɨɝɨ ɫɨɟɞɢɧɟɧɢɹ ɬɢɦɭɫɚ ɤɨɧɬɚɤɬɢɪɨɜɚɥɢ ɫ ɤɪɨɜɟɧɨɫɧɵɦɢ ɤɚɩɢɥɥɹɪɚɦɢ, ɱɬɨ ɩɪɢɧɹɬɨ ɪɚɫɫɦɚɬɪɢɜɚɬɶ
ɤɚɤ ɚɤɬɢɜɚɰɢɸ ɦɟɯɚɧɢɡɦɨɜ ɩɟɪɟɧɨɫɚ ɚɭɬɨɚɧɬɢɝɟɧɨɜ ɢɡ ɤɪɨɜɟɧɨɫɧɨɝɨ ɪɭɫɥɚ ɤ ɜɧɭɬɪɢɬɢɦɭɫɧɵɦ ɥɢɦɮɨɰɢɬɚɦ ɞɥɹ ɮɨɪɦɢɪɨɜɚɧɢɹ
ɭ ɧɢɯ ɟɫɬɟɫɬɜɟɧɧɨɣ ɬɨɥɟɪɚɧɬɧɨɫɬɢ. ɍɜɟɥɢɱɟɧɢɟ ɱɢɫɥɚ ɦɚɤɪɨɮɚɝɨɜ ɜ ɫɭɛɤɚɩɫɭɥɹɪɧɨɣ ɡɨɧɟ,
ɜɟɪɨɹɬɧɨ, ɫɜɹɡɚɧɨ ɫ ɧɚɪɭɲɟɧɢɟɦ ɦɟɯɚɧɢɡɦɨɜ
ɷɜɚɤɭɚɰɢɢ ɬɢɦɢɱɟɫɤɢɯ ɝɨɪɦɨɧɨɜ. ȼ ɥɢɬɟɪɚɬɭɪɟ
ɩɨɤɚɡɚɧɨ, ɱɬɨ ɩɪɢ ɤɭɥɶɬɢɜɢɪɨɜɚɧɢɢ ɦɨɧɨɰɢɬɨɜ ɜ ɫɪɟɞɟ ɫ ɞɨɛɚɜɥɟɧɢɟɦ ɫɭɛɫɬɚɧɰɢɢ ɉ ɨɬɦɟɱɚɟɬɫɹ ɩɨɜɵɲɟɧɢɟ ɢɯ ɮɭɧɤɰɢɨɧɚɥɶɧɨɣ ɚɤɬɢɜɧɨɫɬɢ [23]. ɇɚ 21 ɫɭɬɤɢ ɩɨɫɥɟ ɜɜɟɞɟɧɢɹ ɤɚɩɫɚɢɰɢɧɚ ɫɬɪɭɤɬɭɪɚ ɷɩɢɬɟɥɢɨɰɢɬɨɜ ɬɢɦɭɫɚ ɧɨɪɦɚɥɢɡɨɜɚɥɚɫɶ, ɥɢɲɶ ɧɚ ɨɬɞɟɥɶɧɵɯ ɭɱɚɫɬɤɚɯ
ɩɪɢɫɭɬɫɬɜɨɜɚɥɢ ɷɩɢɬɟɥɢɨɰɢɬɵ, ɨɤɪɭɠɚɸɳɢɟ
ɦɚɤɪɨɮɚɝɢ.
Ɂɚɤɥɸɱɟɧɢɟ
ɉɨɥɭɱɟɧɧɵɟ ɪɟɡɭɥɶɬɚɬɵ ɦɨɠɧɨ ɫɜɹɡɚɬɶ ɫ ɮɚɡɧɵɦɢ ɩɟɪɟɫɬɪɨɣɤɚɦɢ ɭɪɨɜɧɹ ɫɟɧɫɨɪɧɵɯ ɧɟɣɪɨɩɟɩɬɢɞɨɜ ɜ ɪɚɡɧɵɟ ɫɪɨɤɢ ɞɟɣɫɬɜɢɹ ɤɚɩɫɚɢɰɢɧɚ.
ȼɟɪɨɹɬɧɨ, ɜɵɛɪɨɫ ɧɟɣɪɨɩɟɩɬɢɞɨɜ ɫɨɩɪɨɜɨɠɞɚɥɫɹ ɡɧɚɱɢɬɟɥɶɧɵɦ ɭɫɢɥɟɧɢɟɦ ɫɢɧɬɟɬɢɱɟɫɤɢɯ
140
ɩɪɨɰɟɫɫɨɜ ɜ ɷɩɢɬɟɥɢɨɰɢɬɚɯ ɬɢɦɭɫɚ ɢ ɭɦɟɪɟɧɧɵɦ ɭɜɟɥɢɱɟɧɢɟɦ ɮɚɝɨɰɢɬɚɪɧɨɣ ɚɤɬɢɜɧɨɫɬɢ
ɦɚɤɪɨɮɚɝɨɜ, ɩɪɢ ɞɟɮɢɰɢɬɟ ɫɟɧɫɨɪɧɵɯ ɧɟɣɪɨɩɟɩɬɢɞɨɜ ɝɨɪɦɨɧɫɢɧɬɟɡɢɪɭɸɳɚɹ ɚɤɬɢɜɧɨɫɬɶ
ɷɩɢɬɟɥɢɨɰɢɬɨɜ ɫɧɢɠɚɟɬɫɹ, ɬɨɝɞɚ ɤɚɤ ɤɨɥɢɱɟɫɬɜɨ
ɢ ɮɭɧɤɰɢɨɧɚɥɶɧɚɹ ɚɤɬɢɜɧɨɫɬɶ ɦɚɤɪɨɮɚɝɨɜ ɜɨɡɪɚɫɬɚɟɬ. ȼ ɪɚɧɧɢɟ ɫɪɨɤɢ ɞɟɣɫɬɜɢɹ ɩɪɟɩɚɪɚɬɚ
ɧɚ ɮɨɧɟ ɢɧɬɟɧɫɢɜɧɨɝɨ ɜɵɛɪɨɫɚ ɧɟɣɪɨɩɟɩɬɢɞɨɜ
ɢɡ Ʉɑɇ ɨɬɦɟɱɚɥɢ ɪɚɫɲɢɪɟɧɢɟ ɦɢɤɪɨɰɢɪɤɭɥɹɬɨɪɧɨɝɨ ɪɭɫɥɚ. Ɉɫɥɚɛɥɟɧɢɟ ɤɨɧɬɪɨɥɹ ɫɨ ɫɬɨɪɨɧɵ
ɫɟɧɫɨɪɧɵɯ ɧɟɣɪɨɩɟɩɬɢɞɨɜ ɩɪɢɜɨɞɢɥɨ ɤ ɭɦɟɧɶɲɟɧɢɸ ɫɬɪɭɤɬɭɪɧɵɯ ɪɟɡɟɪɜɨɜ ɬɢɦɭɫɚ, ɱɬɨ ɜɵɪɚɠɚɥɨɫɶ ɜ ɫɨɤɪɚɳɟɧɢɢ ɨɛɴɟɦɚ ɫɬɪɭɤɬɭɪɧɨɮɭɧɤɰɢɨɧɚɥɶɧɵɯ ɡɨɧ. ɇɚ ɮɨɧɟ ɞɟɮɢɰɢɬɚ ɧɟɣɪɨɩɟɩɬɢɞɨɜ Ʉɑɇ ɝɨɪɦɨɧɫɢɧɬɟɡɢɪɭɸɳɚɹ ɚɤɬɢɜɧɨɫɬɶ ɷɩɢɬɟɥɢɨɰɢɬɨɜ ɫɧɢɠɚɥɚɫɶ, ɚ ɮɚɝɨɰɢɬɚɪɧɚɹ ɚɤɬɢɜɧɨɫɬɶ ɦɚɤɪɨɮɚɝɨɜ — ɭɫɢɥɢɜɚɥɚɫɶ.
ROLE OF CAPSAICINE RESPONSIVE
NEURONES IN A REGULATION
HORMONAL SYNTHESING ACTIVITY OF
EPITHELIAL CELLS OF A THYMUS
GLAND OF RATS
E.M. Zhukova
Influence of pharmacological blockade
capsaicin-sensitive neurons (ɄSN) on functional
activity of thymic epithelial cells was investigated.
In the first week of action of a capsaicin, on a
background of emission neuropeptides KSN,
amplification activity of hormonal synthesis
thymic epithelial cells thymus revealed by
gistochemical method. The exhaustion of
neuropeptides in endings ɄSN resulted in
decreasing of structural reserves ɬɢɦɭɫɚ and to
reduction of number active thymic epithelial cells.
In all terms of experiment the number
aldegidfucsinplus macrophages in subcapsular
thymic zone grew, that testifies to development of
specific protective reaction - neurogenic
inflammations. Similarity of reaction thymic
epithelial cells in conditions of pharmacological
deafferentation, immunizations, ageing and action
of chronic stress is marked.
Ʌɢɬɟɪɚɬɭɪɚ
1. ɇɨɜɵɯ Ⱥ.Ⱥ. Ɉɫɨɛɟɧɧɨɫɬɢ ɭɥɶɬɪɚɫɬɪɭɤɬɭɪɧɨɣ ɨɪɝɚɧɢɡɚɰɢɢ ɷɩɢɬɟɥɢɨ–ɪɟɬɢɤɭɥɹɪɧɵɯ ɷɥɟɦɟɧɬɨɜ ɬɢɦɭɫɚ /
Ⱥ.Ⱥ. ɇɨɜɵɯ, ɇ.ɇ. ɇɨɜɵɯ, Ɇ.Ⱥ. ɋɚɦɨɪɹɞɨɜɚ // Ɇɨɪɮɨɥɨɝɢɹ. – 2002. – Ɍ.121. – ʋ 2-3. – ɋ. 89.
2. Elfvin L.G. Primary sensory afferents in the thymus
of the guinea pig demonstrated with anterogradely transported
horseradish
peroxidase
conjugates
/
L.G. Elfvin,
H. Aldskogius, J. Johansson // Neurosci. Lett. – 1993. –
Vol. 5. – ʋ 150(1). – P. 35-38.
3. Jurjus A.R. Distribution of substance P possible cells
and nerve fibers in the rat thymus / A.R. Jurjus, N. More,
¡fiÀÀ“Õ‹ –Œ —¿ÃÕ, ʋ 3 (125), 2007 „.
ɀɭɤɨɜɚ ȿ.Ɇ. Ɋɨɥɶ ɤɚɩɫɚɢɰɢɧ-ɱɭɜɫɬɜɢɬɟɥɶɧɵɯ ɧɟɣɪɨɧɨɜ ɜ ɪɟɝɭɥɹɰɢɢ ɝɨɪɦɨɧɫɢɧɬɟɡɢɪɭɸɳɟɣ ɚɤɬɢɜɧɨɫɬɢ
ɷɩɢɬɟɥɢɨɰɢɬɨɜ ɬɢɦɭɫɚ ɤɪɵɫ / ɫ. 138-141
R.J. Walsh // J. Neuroimmunol. – 1998. – Vol.90. – ʋ 2. –
P. 143-148.
4. Cloning and functional expression of a human
orthologue of rat vanilloid receptor-1 / P. Hayes, H. Meadows,
M. Gunthorpe, et al. // Pain. – 2000. – Vol. 88. – ʋ 2. –
P. 205-215.
5. Expression of substance P and its neurokinin-1 receptor on thymocytes: functional relevance in the regulation of
thymocyte apoptosis and proliferation / G. Santoni,
C. Amantini, R. Lucciarini, et al. // Neuroimmunomodulation.
– 2003. – Vol. 10. – ʋ 4. – P.232-246.
6. ɉɢɪɫ ɗ. Ƚɢɫɬɨɯɢɦɢɹ / ɗ. ɉɢɪɫ. Ɇ., 1962. – ɋ. 867.
7. Agonist- induced internalisation of the substance P
(NK-1) receptor expressed in epithelial cells / A.M. Garland,
E.F. Grady, D. Payan, et al. // Biochemical Journal. – 1994. –
Vol. 303. – ʋ 1. – P. 177-186.
8. Characterization of P2 receptors in thymic epithelial
cells / R. Bisaggio, O. Nihei, P. Persechini, et al. //Cell. Mol.
Biol. (Noisy-le-grand). – 2001. – Vol. 47. – ʋ.1. – P.19-31.
9. Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage
structures
/
S. Stander,
C. Moormann,
M. Schumacher, et al. // Exp. Dermatol. – 2004. – Vol. 13. –
ʋ 3. – P. 129-139.
10. Henry K. The human thymus in disease myth particular emphasis on thymus and thymome / K. Henry // The thymus
Gland. / Ed.: M. Kendall. – London, 1981. – P. 85-113.
11. Holzer P. Neuroqenic vasodilatation and plasma
leakage in the skin / P. Holzer // Gen. Pharmacology. – 1998.
¡fiÀÀ“Õ‹ –Œ —¿ÃÕ, ʋ 3 (125), 2007 „.
– Vol. 30. – ʋ 1. – P. 5-11.
12. ɉɟɬɪɨɜ ɋ.Ⱥ. ɋɩɨɫɨɛ ɥɟɱɟɧɢɹ ɦɢɨɩɢɣ ɫ ɢɫɩɨɥɶɡɨɜɚɧɢɟɦ ȻȺȾ / ɋ.Ⱥ. ɉɟɬɪɨɜ, ɘ.Ƚ. ɋɭɯɨɜɟɣ, Ƚ.Ⱥ. Ⱥɪɝɭɧɨɜɚ
// Ɍɟɡ. V ɦɟɠɞɭɧɚɪ. ɫɢɦɩ. «Ȼɢɨɥɨɝɢɱɟɫɤɢ ɚɤɬɢɜɧɵɟ ɞɨɛɚɜɤɢ ɤ ɩɢɳɟ ɢ ɩɪɨɛɥɟɦɵ ɡɞɨɪɨɜɶɹ ɫɟɦɶɢ». – Ʉɪɚɫɧɨɹɪɫɤ,
2001. – ɋ. 204-205.
13. Ɂɚɣɪɚɬɶɹɧɰ Ɉ.ȼ. ɉɪɨɞɭɤɰɢɹ ɬɢɦɭɫɨɦ ɢɦɦɭɧɨɦɨɞɭɥɢɪɭɸɳɢɯ ɩɨɥɢɩɟɩɬɢɞɨɜ ɩɪɢ ɟɝɨ ɨɫɬɪɨɣ ɢɧɜɨɥɸɰɢɢ ɭ
ɞɟɬɟɣ / Ɉ.ȼ. Ɂɚɣɪɚɬɶɹɧɰ, ȼ.ɏ. ɏɚɜɢɧɫɨɧ, Ʌ.Ƚ. Ʉɭɡɶɦɟɧɤɨ //
Ⱥɪɯ. ɩɚɬɨɥ. – 1990. ʋ 1. – ɋ. 25-28.
14. Ƚɪɢɧɟɜɢɱ ɘ.Ⱥ. ɂɦɦɭɧɨɛɢɨɥɨɝɢɹ ɝɨɪɦɨɧɨɜ ɬɢɦɭɫɚ / ɘ.Ⱥ. Ƚɪɢɧɟɜɢɱ, ȼ.Ɏ. ɑɟɛɨɬɚɪɟɜ // Ʉɢɟɜ, 1989. – 124 ɫ.
15. Age-dependent loss in Mew Zealand Mice of morphological functional characteristics of thymine epithelial cells
/ M. Gershwin, R. Ikeda, W. Kruse, et al. // J. Immunol. –
1978. – Vol. 12. – P. 971-973.
16. Nitric oxide induces murine thymocite apoptosis by
oxidative injury and a p53-dependent mechanism /
S.A. Gordon, W. Abou-Jaoude, R. Hoffman, et al. // J.
Leukoc. Biol. – 2001. – Vol. 70. – ʋ 1. – P.87-95.
17. Effect of substance P on cytokine production by human astrocytic cells: Characterization of novel tachykinin receptor antagonists / J.M. Derocq, M. Segui, C. Blazy, et al. //
FEBS Letters. – 1996. – Vol. 399. – ʋ 3. – P. 321-325.
18. Influence of several peptidase inhibitors on the proinflammatory effects of substance P, capsaicin and collagenase / J. Damas, V. Bourdon, J.F. Liegeois, et al. // NaunynSchmiedebergs Arch. of pharm. – 1996. – Vol. 354. – ʋ 5. –
P. 662-669.
141