ЭКСПРЕССИЯ ГЕНОВ RHOA, SEMA3B И CKAP2 ПРИ

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ЭКСПРЕССИЯ ГЕНОВ RHOA, SEMA3B И CKAP2 ПРИ РАЗЛИЧНЫХ ТИПАХ ЛЕЙКОЗОВ
. . .,
Климов Евгений Александрович,
, . . .,
. .
,
EXPRESSION OF RHOA, SEMA3B, AND CKAP2 GENES IN LEUKEMIA OF DIFFERENT TYPES
Eugene Klimov, Doc. of Sci., Group Leader, Faculty of Biology of Lomonosov Moscow State University, University Diagnostic
Laboratory
SEMA3B
.
.
.
.
RHOA, SEMA3B CKAP2
RHOA CKAP2,
.
CKAP2
-
ABSTRACT
Transcriptional activity of RHOA, SEMA3B, and CKAP2 genes was assessed in blood samples of leukemia patients and
healthy donors. In blood of healthy donors, RHOA and CKAP2 gene expression was not detected, and a low SEMA3B gene
expression was observed. Significant elevation of expression of all three genes was shown in case of acute myelogenous leukemia.
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"Educatio" II (9), 2015
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АУКИ
In cases of remission of acute lymphoblastic leukemia and myelodysplastic syndrome, expression of all three genes was not
detected. Long isoform of CKAP2 gene is highly expressed in most analyzed types of leukemia.
:
,
,
, RHOA, SEMA3B, CKAP2
Keywords: leukemia, gene expression, RT-PCR, RHOA, SEMA3B, CKAP2
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«TrТгШХ RNA PrОЩ»
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RHOA, SEMA3B
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CKAPқ
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CKAP2-F: TTCTGAATGCCTGAACTTGAT, CKAP2f-R:
TTAACATCATGGGTTGGATCT, CKAP2s-R: AATTCCGAATTGTCTACTACACTG;
95° /Қ5”, 5қ° /Қ0”, 7қ° /30” (F) қ0” (S- ).
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"Educatio" II (9), 2015
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RHOA, SEMA3B
1. Etienne-Manneville S., Hall A. Rho GTPases in cell
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.
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/
.
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ИЦИ СКИ
80
CKAPқ (
АУКИ
)
.
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12. Castro-Rivera E., Ran S., Thorpe P. et al. Semaphorin
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13.
. .,
. .,
. .
.
SEMA3B
.
.
2009;43(3):439-445.
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associated protein, differentially expressed in diffuse
large B cell lymphomas. Oncogene. 1998;17(10):12451251.
15.
. .,
. .,
. .
.
CKAPқ (LBҚ),
.
. қ00қ;36(6):985-989.
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mouse cytoskeleton-associated protein, CKAP2, with
microtubule-stabilizing properties. Cancer Sci.
2004;95(10):815-821.
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ФАРМАКОЛОГИЧЕСКАЯ КОРРЕКЦИЯ ФЕТОПЛАЦЕНТАРНОЙ НЕДОСТАТОЧНОСТИ
С СИНДРОМОМ ЗАДЕРЖКИ РОСТА ПЛОДА
Клычева Ольга Игоревна
,
, .
. . .,
,
. . .,
.
Лазарева Галина Анатольевна
,
, .
Хурасева Анна Борисовна
,
, .
PHARMACOLOGICAL CORRECTION OF FETOPLACENTAL INSUFFICIENCY WITH FETAL GROWTH RETARDATION
SYNDROME
Klichiova Olga, postgraduate student Department of Obstetrics and Gynecology, Faculty of Postgraduate Education, Kursk
State Medical University, Kursk
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