Ⱥȼ. ȽɂȾɊȺɇɈȼɂɑ ÌÅÒÀÁÎËÈ×ÅÑÊÀß ÀÊÒÈÂÍÎÑÒÜ ÃËÈÊÎËÈÇÀ  ÑÛÂÎÐÎÒÊÅ ÊÐÎÂÈ ÁÎËÜÍÛÕ ÐÀÊÎÌ ÌÎËÎ×ÍÎÉ ÆÅËÅÇÛ

Ⱥȼ. ȽɂȾɊȺɇɈȼɂɑ
ÌÅÒÀÁÎËÈ×ÅÑÊÀß ÀÊÒÈÂÍÎÑÒÜ ÃËÈÊÎËÈÇÀ  ÑÛÂÎÐÎÒÊÅ ÊÐÎÂÈ
ÁÎËÜÍÛÕ ÐÀÊÎÌ ÌÎËÎ×ÍÎÉ ÆÅËÅÇÛ
ɍɈ «ȼɢɬɟɛɫɤɢɣ ɝɨɫɭɞɚɪɫɬɜɟɧɧɵɣ ɦɟɞɢɰɢɧɫɤɢɣ ɭɧɢɜɟɪɫɢɬɟɬ»,
Ɋɟɫɩɭɛɥɢɤɚ Ȼɟɥɚɪɭɫɶ
ɂɡɭɱɟɧɚ ɚɤɬɢɜɧɨɫɬɶ ɝɥɸɤɨɡɨɮɨɫɮɚɬɢɡɨɦɟɪɚɡɵ, ɮɪɭɤɬɨɡɨ-1,6-ɛɢɫɮɨɫɮɚɬɚɥɶɞɨɥɚɡɵ ɢ ɥɚɤɬɚɬɞɟɝɢɞɪɨɝɟɧɚɡɵ ɜ ɫɵɜɨɪɨɬɤɟ ɤɪɨɜɢ ɛɨɥɶɧɵɯ ɪɚɤɨɦ ɦɨɥɨɱɧɨɣ ɠɟɥɟɡɵ ɢ ɡɞɨɪɨɜɵɯ ɠɟɧɳɢɧ ɞɨɧɨɪɨɜ 40 – 55 ɥɟɬ. ɍɫɬɚɧɨɜɥɟɧɨ ɩɨɜɵɲɟɧɢɟ ɚɤɬɢɜɧɨɫɬɢ ɝɥɸɤɨɡɨɮɨɫɮɚɬɢɡɨɦɟɪɚɡɵ ɜ ɫɵɜɨɪɨɬɤɟ
ɤɪɨɜɢ ɛɨɥɶɧɵɯ ɪɚɤɨɦ ɦɨɥɨɱɧɨɣ ɠɟɥɟɡɵ ɩɨ ɫɪɚɜɧɟɧɢɸ ɫɨ ɡɞɨɪɨɜɵɦɢ ɞɨɧɨɪɚɦɢ. ɇɚɢɛɨɥɶɲɚɹ ɚɤɬɢɜɧɨɫɬɶ ɝɥɸɤɨɡɨɮɨɫɮɚɬɢɡɨɦɟɪɚɡɵ ɧɚɛɥɸɞɚɥɚɫɶ ɭ ɛɨɥɶɧɵɯ 4-ɨɣ ɫɬɚɞɢɟɣ ɡɚɛɨɥɟɜɚɧɢɹ. Ⱥɤɬɢɜɧɨɫɬɶ ɮɪɭɤɬɨɡɨ-1,6-ɛɢɫɮɨɫɮɚɬɚɥɶɞɨɥɚɡɵ ɢɦɟɥɚ ɬɟɧɞɟɧɰɢɸ ɤ ɭɜɟɥɢɱɟɧɢɸ ɭ ɛɨɥɶɧɵɯ ɨɩɟɪɚɛɟɥɶɧɵɦ ɪɚɤɨɦ ɦɨɥɨɱɧɨɣ ɠɟɥɟɡɵ 1 – 3-ɟɣ ɫɬɚɞɢɢ. Ⱥɤɬɢɜɧɨɫɬɶ ɥɚɤɬɚɬɞɟɝɢɞɪɨɝɟɧɚɡɵ ɭ ɛɨɥɶɧɵɯ ɪɚɤɨɦ
ɦɨɥɨɱɧɨɣ ɠɟɥɟɡɵ ɩɪɟɜɵɲɚɥɚ ɚɤɬɢɜɧɨɫɬɶ ɬɚɤɨɜɨɣ ɭ ɡɞɨɪɨɜɵɯ ɞɨɧɨɪɨɜ. ɍɦɟɧɶɲɟɧɢɟ ɫɨɨɬɧɨɲɟɧɢɹ ɚɤɬɢɜɧɨɫɬɢ ɥɚɤɬɚɬɞɟɝɢɞɪɨɝɟɧɚɡɵ ɢ ɝɥɸɤɨɡɨɮɨɫɮɚɬɢɡɨɦɟɪɚɡɵ ɩɪɢ ɭɜɟɥɢɱɟɧɢɢ ɫɬɚɞɢɢ ɡɚɛɨɥɟɜɚɧɢɹ ɦɨɠɟɬ ɫɜɢɞɟɬɟɥɶɫɬɜɨɜɚɬɶ ɨ ɛɨɥɶɲɟɣ ɷɤɫɩɪɟɫɫɢɢ ɝɥɸɤɨɡɨɮɨɫɮɚɬɢɡɨɦɟɪɚɡɵ ɜ ɨɩɭɯɨɥɟɜɵɯ ɤɥɟɬɤɚɯ ɢ, ɜɨɡɦɨɠɧɨ, ɫɜɹɡɚɧɨ ɫ ɚɝɪɟɫɫɢɜɧɵɦ ɮɟɧɨɬɢɩɨɦ ɨɩɭɯɨɥɢ.
Ʉɥɸɱɟɜɵɟ ɫɥɨɜɚ: ɪɚɤ ɦɨɥɨɱɧɨɣ ɠɟɥɟɡɵ, ɝɥɢɤɨɥɢɡ, ɝɥɸɤɨɡɨɮɨɫɮɚɬɢɡɨɦɟɪɚɡɚ, ɮɪɭɤɬɨɡɨ-1,6-ɮɢɫɮɨɫɮɚɬɚɥɶɞɨɥɚɡɚ, ɥɚɤɬɚɬɞɟɝɢɞɪɨɝɟɧɚɡɚ.
We studied the activity of glucosephosphate isomerase, fructose-1, 6-bisphosphate aldolase and
lactate dehydrogenase in serum of breast cancer patients and healthy female donors at the age of 40–55.
The rise of activity of glucosephosphate isomerase was observed in breast cancer patients in comparison
with healthy donors. The highest activity of glucosephosphate isomerase was observed in patients with
the 4th stage of breast cancer. Activity of fructose-1, 6-bisphosphate aldolase had the tendency to rise in
the patients with operable breast cancer of the 1st – 3rd stages. Activity of lactate dehydrogenase was
higher in breast cancer patients when compared with healthy donors. The decrease of ratio of lactate
dehydrogenase to glucosephosphate isomerase may be due to increased expression of glucosephosphate
isomerase in malignant cells that may testify to aggressive tumor phenotype.
Keywords: breast cancer, glycolysis, glucosephosphate isomerase, fructose-1, 6-bisphosphate
aldolase, lactate dehydrogenase.
ɉɪɟɜɪɚɳɟɧɢɟ ɝɥɸɤɨɡɵ ɜ ɥɚɤɬɚɬ ɜ ɩɪɢɫɭɬɫɬɜɢɢ ɤɢɫɥɨɪɨɞɚ ɢɡɜɟɫɬɧɨ ɤɚɤ ɚɷɪɨɛɧɵɣ
ɝɥɢɤɨɥɢɡ. Ⱥɤɬɢɜɚɰɢɹ ɚɷɪɨɛɧɨɝɨ ɝɥɢɤɨɥɢɡɚ
ɯɚɪɚɤɬɟɪɧɚ ɞɥɹ ɡɥɨɤɚɱɟɫɬɜɟɧɧɵɯ ɪɚɤɨɜɵɯ
ɤɥɟɬɨɤ. ɗɬɨɬ ɮɟɧɨɦɟɧ ɜɩɟɪɜɵɟ ɨɩɢɫɚɧ
O.H. Warburg ɜ 1920 ɝɨɞɭ [1], ɱɬɨ ɩɪɢɜɟɥɨ
ɟɝɨ ɤ ɝɢɩɨɬɟɡɟ ɨ ɬɨɦ, ɱɬɨ ɪɚɤ ɜɨɡɧɢɤɚɟɬ ɜɜɢ88
ɞɭ ɧɚɪɭɲɟɧɢɹ ɦɟɬɚɛɨɥɢɡɦɚ ɜ ɦɢɬɨɯɨɧɞɪɢɹɯ. ɇɟɫɦɨɬɪɹ ɧɚ ɬɨ ɱɬɨ ɝɢɩɨɬɟɡɚ O.H. Warburg
ɧɟ ɛɵɥɚ ɩɨɞɬɜɟɪɠɞɟɧɚ ɜ ɩɨɥɧɨɣ ɦɟɪɟ, ɷɤɫɩɟɪɢɦɟɧɬɚɥɶɧɵɟ ɢɫɫɥɟɞɨɜɚɧɢɹ ɧɟɨɞɧɨɤɪɚɬɧɨ ɩɨɞɬɜɟɪɠɞɚɥɢ ɭɫɢɥɟɧɢɟ ɝɥɢɤɨɥɢɡɚ ɜ
ɨɩɭɯɨɥɟɜɵɯ ɤɥɟɬɤɚɯ ɜ ɩɪɢɫɭɬɫɬɜɢɢ ɤɢɫɥɨɪɨɞɚ [2]. ɂɫɩɨɥɶɡɨɜɚɧɢɟ ɬɟɯɧɨɥɨɝɢɢ ɩɨɡɢɬ-
ʋ1x 2008 i ɬɨɦ 16
ɪɨɧ ɷɦɢɫɫɢɨɧɧɨɣ ɬɨɦɨɝɪɚɮɢɢ ɩɨɡɜɨɥɢɥɨ
ɩɨɤɚɡɚɬɶ, ɱɬɨ ɛɨɥɶɲɢɧɫɬɜɨ ɩɟɪɜɢɱɧɵɯ ɢ
ɦɟɬɚɫɬɚɬɢɱɟɫɤɢɯ ɨɩɭɯɨɥɟɣ ɢɦɟɟɬ ɩɨɜɵɲɟɧɧɵɣ ɡɚɯɜɚɬ ɝɥɸɤɨɡɵ [3]. Ⱥɤɬɢɜɧɵɣ ɡɚɯɜɚɬ
ɝɥɸɤɨɡɵ ɨɛɭɫɥɚɜɥɢɜɚɟɬɫɹ ɜɵɫɨɤɢɦ ɭɪɨɜɧɟɦ
ɝɥɢɤɨɥɢɡɚ, ɩɨɜɵɲɟɧɢɟɦ ɦɟɬɚɛɨɥɢɱɟɫɤɨɣ
ɚɤɬɢɜɧɨɫɬɢ ɩɟɪɟɧɨɫɱɢɤɨɜ ɝɥɸɤɨɡɵ (GLUT1
ɢ GLUT3) ɢ ɝɟɤɫɨɤɢɧɚɡ I ɢ II [4].
ɇɟɢɧɜɚɡɢɜɧɵɟ ɤɥɟɬɤɢ ɪɚɤɚ ɦɨɥɨɱɧɨɣ
ɠɟɥɟɡɵ MCF-7 ɢɦɟɸɬ ɡɧɚɱɢɬɟɥɶɧɨ ɛɨɥɟɟ
ɧɢɡɤɢɣ ɭɪɨɜɟɧɶ ɚɷɪɨɛɧɨɝɨ ɝɥɢɤɨɥɢɡɚ, ɱɟɦ
ɜɵɫɨɤɨɢɧɜɚɡɢɜɧɵɟ ɤɥɟɬɤɢ ɥɢɧɢɢ MDA-mb231. ɗɬɢ ɧɚɛɥɸɞɟɧɢɹ ɩɨɤɚɡɵɜɚɸɬ, ɱɬɨ ɢɡɦɟɧɟɧɧɵɣ ɦɟɬɚɛɨɥɢɡɦ ɝɥɸɤɨɡɵ ɜ ɨɩɭɯɨɥɟɜɵɯ ɤɥɟɬɤɚɯ ɹɜɥɹɟɬɫɹ ɜɚɠɧɵɦ ɩɚɬɨɮɢɡɢɨɥɨɝɢɱɟɫɤɢɦ ɮɟɧɨɦɟɧɨɦ, ɚ ɧɟ ɬɨɥɶɤɨ ɚɞɚɩɬɚɰɢɨɧɧɵɦ ɦɟɯɚɧɢɡɦɨɦ ɤ ɝɢɩɨɤɫɢɢ. Ⱥɤɬɢɜɚɰɢɹ ɝɥɢɤɨɥɢɡɚ ɞɚɟɬ ɡɥɨɤɚɱɟɫɬɜɟɧɧɵɦ
ɤɥɟɬɤɚɦ ɡɧɚɱɢɬɟɥɶɧɵɣ ɩɪɨɥɢɮɟɪɚɬɢɜɧɵɣ
ɩɨɬɟɧɰɢɚɥ. ɉɨɜɵɲɟɧɧɚɹ ɚɤɬɢɜɧɨɫɬɶ ɡɚɯɜɚɬɚ ɝɥɸɤɨɡɵ ɨɩɭɯɨɥɶɸ, ɚ ɫɨɨɬɜɟɬɫɬɜɟɧɧɨ ɚɤɬɢɜɢɡɚɰɢɹ ɚɷɪɨɛɧɨɝɨ ɝɥɢɤɨɥɢɡɚ ɫɜɹɡɚɧɵ ɫ
ɧɟɛɥɚɝɨɩɪɢɹɬɧɵɦ ɩɪɨɝɧɨɡɨɦ [5].
Ƚɥɢɤɨɥɢɡ ɹɜɥɹɟɬɫɹ ɝɥɚɜɧɵɦ ɦɟɬɚɛɨɥɢɱɟɫɤɢɦ ɩɭɬɟɦ ɡɥɨɤɚɱɟɫɬɜɟɧɧɨɣ ɤɥɟɬɤɢ. Ɉɧ
ɨɛɟɫɩɟɱɢɜɚɟɬ ɧɟ ɬɨɥɶɤɨ ɷɧɟɪɝɟɬɢɱɟɫɤɢɟ
ɩɨɬɪɟɛɧɨɫɬɢ ɛɵɫɬɪɨ ɞɟɥɹɳɟɣɫɹ ɤɥɟɬɤɢ, ɧɨ
ɬɚɤɠɟ ɹɜɥɹɟɬɫɹ ɩɨɫɬɚɜɳɢɤɨɦ ɜɟɳɟɫɬɜ ɞɥɹ
ɚɧɚɛɨɥɢɱɟɫɤɢɯ ɩɪɨɰɟɫɫɨɜ, ɪɨɫɬɚ ɢ ɪɚɡɦɧɨɠɟɧɢɹ ɤɥɟɬɨɤ (ɪɢɫ. 1). Ƚɥɢɤɨɥɢɬɢɱɟɫɤɢɟ
ɩɪɨɰɟɫɫɵ ɹɜɥɹɸɬɫɹ ɠɢɡɧɟɧɧɨ ɧɟɨɛɯɨɞɢɦɵɦɢ ɞɥɹ ɫɭɳɟɫɬɜɨɜɚɧɢɹ ɡɥɨɤɚɱɟɫɬɜɟɧɧɨɣ
ɤɥɟɬɤɢ. ɗɬɨɬ ɷɧɟɪɝɟɬɢɱɟɫɤɢ ɧɟɜɵɝɨɞɧɵɣ
ɩɭɬɶ ɨɛɟɫɩɟɱɢɜɚɟɬ ɩɨɥɭɱɟɧɢɟ ɜɫɟɝɨ 2 ɦɨɥɟɤɭɥ ȺɌɎ ɜɦɟɫɬɨ 36-38 ɦɨɥɟɤɭɥ ȺɌɎ ɩɪɢ
ɨɤɢɫɥɢɬɟɥɶɧɨɦ ɮɨɫɮɨɪɢɥɢɪɨɜɚɧɢɢ, ɨɞɧɚɤɨ, ɜɜɢɞɭ ɬɨɝɨ ɱɬɨ ɨɩɭɯɨɥɶ ɛɵɫɬɪɨ ɪɚɫɬɟɬ, ɚ
ɩɪɨɰɟɫɫɵ ɧɟɨɜɚɫɤɭɥɹɪɢɡɚɰɢɢ ɧɟ ɭɫɩɟɜɚɸɬ
ɨɛɟɫɩɟɱɢɜɚɬɶ ɟɟ ɞɨɫɬɚɬɨɱɧɵɦ ɭɪɨɜɧɟɦ ɤɢɫɥɨɪɨɞɚ, ɡɥɨɤɚɱɟɫɬɜɟɧɧɵɟ ɤɥɟɬɤɢ ɧɚɯɨɞɹɬɫɹ
ɜ ɯɪɨɧɢɱɟɫɤɨɦ ɝɢɩɨɤɫɢɱɟɫɤɨɦ ɫɨɫɬɨɹɧɢɢ, ɢ
ɬɨɥɶɤɨ ɝɥɢɤɨɥɢɡ ɩɨɞɞɟɪɠɢɜɚɟɬ ɢɯ ɠɢɡɧɟɞɟɹɬɟɥɶɧɨɫɬɶ.
Ɋɟɝɭɥɹɰɢɹ ɝɥɢɤɨɥɢɡɚ ɭ ɨɩɭɯɨɥɟɜɵɯ ɤɥɟɬɨɤ ɢɦɟɟɬ ɧɟɤɨɬɨɪɵɟ ɨɫɨɛɟɧɧɨɫɬɢ, ɤɨɬɨɪɵɟ
ɩɨɡɜɨɥɹɸɬ ɩɨɞɞɟɪɠɢɜɚɬɶ ɜɵɫɨɤɢɣ ɭɪɨɜɟɧɶ
ɝɥɢɤɨɥɢɡɚ ɜ ɪɚɡɥɢɱɧɵɯ ɭɫɥɨɜɢɹɯ. Ɉ. ȼɚɪɛɭɪɝ
ɜ 1862 ɝɨɞɭ ɨɛɧɚɪɭɠɢɥ, ɱɬɨ ɜ ɚɷɪɨɛɧɵɯ ɭɫɥɨɜɢɹɯ ɨɩɭɯɨɥɟɜɵɟ ɤɥɟɬɤɢ ɩɪɟɜɪɚɳɚɸɬ
ɛɨɥɶɲɟ ɝɥɸɤɨɡɵ ɜ ɦɨɥɨɱɧɭɸ ɤɢɫɥɨɬɭ, ɱɟɦ
ɧɨɪɦɚɥɶɧɵɟ. ȼ 1929 ɝɨɞɭ Ƚ. Ʉɪɷɛɬɪɢ ɩɨɤɚɡɚɥ, ɱɬɨ ɝɥɸɤɨɡɚ ɭɦɟɧɶɲɚɟɬ ɩɨɬɪɟɛɥɟɧɢɟ
ɤɢɫɥɨɪɨɞɚ ɢɧɬɟɧɫɢɜɧɨ ɞɵɲɚɳɢɦɢ ɪɚɤɨɜɵɦɢ ɤɥɟɬɤɚɦɢ. ȼ 1861 ɝɨɞɭ ɉɚɫɬɟɪ ɭɫɬɚɧɨ-
Ƚɥɸɤɨɡɚ
Ƚɥɸɤɨɡɨ-6-ɮɨɫɮɚɬ
ɉɟɧɬɨɡɨɮɨɫɮɚɬɵ
Ɏɪɭɤɬɨɡɨ-6-ɮɨɫɮɚɬ
Ⱥɦɢɧɨɫɚɯɚɪɚ
Ƚɥɢɤɨɥɢɩɢɞɵ
ɉɟɧɬɨɡɨɮɨɫɮɚɬɵ
Ɏɪɭɤɬɨɡɨ-1,6-ɛɢɫɮɨɫɮɚɬ
Ƚɥɢɰɟɪɚɥɶɞɟɝɢɞ-3-ɮɨɫɮɚɬ
2,3-Ȼɢɫɮɨɫɮɨɝɥɢɰɟɪɚɬ
ɇɭɤɥɟɢɧɨɜɵɟ ɤɢɫɥɨɬɵ
Ƚɥɢɤɨɩɪɨɬɟɢɧɵ
ɇɭ ɤɥɟɨɬɢɞɵ
Ⱦɢɝɢɞɪɨɚɰɟɬɨɧɮɨɫɮɚɬ
1,3-Ȼɢɫɮɨɫɮɨɝɥɢɰɟɪɚɬ
3-Ɏɨɫɮɨɝɥɢɰɟɪɚɬ
ɇɭɤɥɟɨɬɢɞɵ
ɇɭɤɥɟɢɧɨɜɵɟ ɤɢɫɥɨɬɵ
Ƚɥɢɰ ɟɪɨɥ-3-ɮɨɫɮɚɬ
Ʌɢɩɢɞɵ
ɋɪɨɞɫɬɜɨ ɝɟɦɨɝɥɨɛɢɧɚ ɤ ɤɢɫɥ ɨɪɨɞɭ
Ɉɤɫɢɝɟɧɚɰɢɹ ɬɤɚɧɟɣ
ɋɟɪɢɧ
2-Ɏɨɫɮɨɝɥɢɰɟɪɚɬ
Ɏɨɫɮɨɟɧɨɥɩɢɪɭɜɚɬ
ɉɢɪɭɜɚɬ
Ʌɚɤɬɚɬ
Ⱥɥ ɚɧɢɧ
Ɉɤɫɚɥɨɚɰɟɬɚɬ
Ⱥɫɩɚɪɬɚɬ
ɉɢɪɢɦɢɞɢɧɨɜɵ ɟ ɨɫɧɨɜɚɧɢɹ
Ɋɢɫ.1. Ⱥɧɚɛɨɥɢɱɟɫɤɚɹ ɢ ɪɟɝɭɥɹɬɨɪɧɚɹ ɪɨɥɶ ɝɥɢɤɨɥɢɡɚ.
89
” ɇɨɜɨɫɬɢ ɯɢɪɭɪɝɢɢ
ɜɢɥ, ɱɬɨ ɤɥɟɬɤɢ ɞɪɨɠɠɟɣ ɜ ɚɷɪɨɛɧɵɯ ɭɫɥɨɜɢɹɯ ɩɨɬɪɟɛɥɹɸɬ ɦɟɧɶɲɟ ɝɥɸɤɨɡɵ, ɱɟɦ ɜ
ɚɧɚɷɪɨɛɧɵɯ, ɬɟ. ɬɨɪɦɨɠɟɧɢɟ ɝɥɢɤɨɥɢɡɚ
ɞɵɯɚɧɢɟɦ. ɗɮɮɟɤɬ ɉɚɫɬɟɪɚ ɦɨɠɧɨ ɩɪɟɞɫɬɚɜɢɬɶ ɤɚɤ ɪɟɡɭɥɶɬɚɬ ɩɨɫɥɟɞɨɜɚɬɟɥɶɧɵɯ ɫɬɭɩɟɧɱɚɬɵɯ ɩɪɨɰɟɫɫɨɜ, ɩɪɨɢɫɯɨɞɹɳɢɯ ɜɨ ɜɪɟɦɹ ɨɤɢɫɥɢɬɟɥɶɧɨɝɨ ɮɨɫɮɨɪɢɥɢɪɨɜɚɧɢɹ:
1) ɢɫɬɨɳɟɧɢɟ ɧɟɨɪɝɚɧɢɱɟɫɤɨɝɨ ɮɨɫɮɚɬɚ ɢ ADP, ɧɟɨɛɯɨɞɢɦɵɯ ɞɥɹ ɝɥɢɤɨɥɢɡɚ ɢ
ɩɨɜɵɲɟɧɢɟ ɭɪɨɜɧɹ ATP,
2) ɢɧɚɤɬɢɜɚɰɢɹ ɮɨɫɮɨɮɪɭɤɬɨɤɢɧɚɡɵ
ɩɨɫɪɟɞɫɬɜɨɦ ATP, ɱɬɨ ɩɪɨɹɜɥɹɟɬɫɹ ɜ ɧɚɤɨɩɥɟɧɢɢ ɝɥɸɤɨɡɨ-6-ɮɨɫɮɚɬɚ,
3) ɢɧɚɤɬɢɜɚɰɢɹ ɝɟɤɫɨɤɢɧɚɡɵ ɝɥɸɤɨɡɨ-6ɮɨɫɮɚɬɨɦ.
Ⱦɥɹ ɡɥɨɤɚɱɟɫɬɜɟɧɧɵɯ ɤɥɟɬɨɤ ɯɚɪɚɤɬɟɪɧɨ ɨɬɫɭɬɫɬɜɢɟ ɬɨɪɦɨɠɟɧɢɹ ɝɥɢɤɨɥɢɡɚ ɞɵɯɚɧɢɟɦ (ɷɮɮɟɤɬɚ ɉɚɫɬɟɪɚ), ɱɬɨ ɫɜɹɡɚɧɨ ɫɨ
ɡɧɚɱɢɬɟɥɶɧɵɦ ɢɡɦɟɧɟɧɢɟɦ ɫɢɫɬɟɦɵ ɪɟɝɭɥɹɰɢɢ ɩɪɨɰɟɫɫɨɜ ɝɥɢɤɨɥɢɡɚ, ɧɨ ɧɚɥɢɱɢɟ
ɷɮɮɟɤɬɚ ȼɚɪɛɭɪɝɚ ɢ Ʉɪɷɛɬɪɢ [6].
ɋɢɫɬɟɦɚ ɪɟɝɭɥɹɰɢɢ ɝɥɢɤɨɥɢɡɚ ɨɫɭɳɟɫɬɜɥɹɟɬɫɹ ɱɟɪɟɡ ɩɭɬɶ ɮɚɤɬɨɪɚ, ɢɧɞɭɰɢɪɭɟɦɨɝɨ ɝɢɩɨɤɫɢɟɣ – 1D (HIF-1D). ȼ ɭɫɥɨɜɢɹɯ
ɧɨɪɦɨɤɫɢɢ HIF-1D ɛɵɫɬɪɨ ɭɬɢɥɢɡɭɟɬɫɹ
ɭɛɢɤɜɢɬɢɧɩɪɨɬɟɨɫɨɦɧɨɣ ɫɢɫɬɟɦɨɣ. ȼ ɭɫɥɨɜɢɹɯ ɝɢɩɨɤɫɢɢ ɧɚɛɥɸɞɚɟɬɫɹ ɬɪɚɧɫɥɨɤɚɰɢɹ HIF-1D ɜ ɹɞɪɨ ɢ ɫɜɹɡɵɜɚɧɢɟ ɫ ɩɪɨɦɨɬɨɪɧɵɦɢ ɭɱɚɫɬɤɚɦɢ ɝɟɧɨɜ (ɷɥɟɦɟɧɬɚɦɢ ɨɬɜɟɬɚ ɧɚ ɝɢɩɨɤɫɢɸ, HRE) ɢ ɢɯ ɬɪɚɧɫɤɪɢɩɰɢɨɧɧɚɹ ɚɤɬɢɜɚɰɢɹ. Ƚɟɧɵ, ɤɨɞɢɪɭɸɳɢɟ ɮɟɪɦɟɧɬɵ ɝɥɢɤɨɥɢɡɚ, ɢɦɟɸɬ HRE ɢ ɪɟɝɭɥɢɪɭɸɬɫɹ ɫɢɫɬɟɦɨɣ HIF-1D/HRE. ɉɨɜɵɲɟɧɢɟ
ɚɤɬɢɜɧɨɫɬɢ ɝɥɢɤɨɥɢɬɢɱɟɫɤɢɯ ɩɪɨɰɟɫɫɨɜ
ɧɟɨɛɯɨɞɢɦɨ ɡɥɨɤɚɱɟɫɬɜɟɧɧɵɦ ɤɥɟɬɤɚɦ ɞɥɹ
ɨɛɟɫɩɟɱɟɧɢɹ ɩɥɚɫɬɢɱɟɫɤɢɯ ɢ ɷɧɟɪɝɟɬɢɱɟɫɤɢɯ ɩɨɬɪɟɛɧɨɫɬɟɣ ɜ ɭɫɥɨɜɢɹɯ ɛɵɫɬɪɨɝɨ ɞɟɥɟɧɢɹ ɢ ɧɟɞɨɫɬɚɬɤɚ ɤɢɫɥɨɪɨɞɚ. Ʉɥɟɬɤɢ ɫ
ɛɨɥɟɟ ɜɵɫɨɤɢɦ ɭɪɨɜɧɟɦ ɚɷɪɨɛɧɨɝɨ ɝɥɢɤɨɥɢɡɚ ɨɛɥɚɞɚɸɬ ɛɨɥɟɟ ɚɝɪɟɫɫɢɜɧɵɦ ɮɟɧɨɬɢɩɨɦ, ɜɵɫɨɤɢɦ ɢɧɜɚɡɢɜɧɵɦ ɢ ɦɟɬɚɫɬɚɬɢɱɟɫɤɢɦ ɩɨɬɟɧɰɢɚɥɨɦ.
Ƚɥɸɤɨɡɨɮɨɫɮɚɬɢɡɨɦɟɪɚɡɚ ɤɚɬɚɥɢɡɢɪɭɟɬ ɨɛɪɚɬɢɦɭɸ ɪɟɚɤɰɢɸ ɢɡɨɦɟɪɢɡɚɰɢɢ
ɲɟɫɬɢɱɥɟɧɧɨɝɨ ɩɢɪɚɧɨɡɧɨɝɨ ɰɢɤɥɚ ɝɥɸɤɨ90
ɡɨ-6-ɮɨɫɮɚɬɚ ɜ ɩɹɬɢɱɥɟɧɧɵɣ ɮɭɪɚɧɨɡɧɵɣ
ɰɢɤɥ ɮɪɭɤɬɨɡɨ-6-ɮɨɫɮɚɬɚ, ɤɨɬɨɪɚɹ ɩɪɨɬɟɤɚɟɬ ɜ ɞɜɟ ɫɬɭɩɟɧɢ ɫ ɪɚɡɪɵɜɨɦ ɩɨɥɭɚɰɟɬɚɥɶɧɨɣ ɫɬɪɭɤɬɭɪɵ ɢ ɨɛɪɚɡɨɜɚɧɢɟɦ ɟɧɞɢɨɥɚ ɢ
ɧɚɩɨɦɢɧɚɟɬ ɤɚɬɚɥɢɡɢɪɭɟɦɭɸ ɳɟɥɨɱɶɸ ɢɡɨɦɟɪɢɡɚɰɢɸ ɜɨ ɮɪɭɤɬɨɡɭ ɢ ɦɚɧɧɨɡɭ.
CH 2OPO32O
H
H
OH
OH
H
H
OH
H
OH
Ƚɥɸɤɨɡɨ-6-ɮɨɫɮɚɬ
CH2OPO3 2OH
O
H
OH
Ƚɥɸɤɨɡɨɮɨɫɮɚɬɢɡɨɦɟɪɚɡɚ
H
CH2OH
OH
H
Ɏɪɭɤɬɨɡɨ-6-ɮɨɫɮɚɬ
Ƚɥɸɤɨɡɨɮɨɫɮɚɬɢɡɨɦɟɪɚɡɚ ɩɪɟɞɫɬɚɜɥɹɟɬ
ɫɨɛɨɣ ɨɞɢɧ ɢɡ ɧɚɢɛɨɥɟɟ ɚɤɬɢɜɧɵɯ ɢ ɲɢɪɨɤɨ ɪɚɫɩɪɨɫɬɪɚɧɟɧɧɵɯ ɮɟɪɦɟɧɬɨɜ ɜ ɪɚɡɥɢɱɧɵɯ ɨɪɝɚɧɚɯ ɢ ɬɤɚɧɹɯ. Ⱦɢɧɚɦɢɱɟɫɤɨɟ ɪɚɜɧɨɜɟɫɢɟ ɪɟɚɤɰɢɢ ɭɫɬɚɧɚɜɥɢɜɚɟɬɫɹ ɨɱɟɧɶ
ɛɵɫɬɪɨ ɩɪɢ ɫɨɞɟɪɠɚɧɢɢ ɜ ɪɟɚɤɰɢɨɧɧɨɣ
ɫɪɟɞɟ ɩɪɢɦɟɪɧɨ 70% Ƚ-6-Ɏ ɢ 30% Ɏ-6-Ɏ.
ɍ ɥɸɞɟɣ ɧɟɞɨɫɬɚɬɨɱɧɨɫɬɶ ɝɥɸɤɨɡɨɮɨɫɮɚɬɢɡɨɦɟɪɚɡɵ ɜɵɡɵɜɚɟɬ ɯɪɨɧɢɱɟɫɤɭɸ ɝɟɦɨɥɢɬɢɱɟɫɤɭɸ ɚɧɟɦɢɸ ɫ ɩɨɜɬɨɪɹɸɳɢɦɢɫɹ
ɝɟɦɨɥɢɬɢɱɟɫɤɢɦɢ ɤɪɢɡɚɦɢ. Ⱦɟɮɟɤɬɧɵɣ ɮɟɪɦɟɧɬ ɢɦɟɟɬ ɩɨɜɵɲɟɧɧɨɟ ɫɪɨɞɫɬɜɨ ɤ ɝɥɸɤɨɡɨ-6-ɮɨɫɮɚɬɭ.
Ɏɪɭɤɬɨɡɨɛɢɫɮɨɫɮɚɬɚɥɶɞɨɥɚɡɚ ɤɚɬɚɥɢɡɢɪɭɟɬ ɪɟɬɪɨɚɥɶɞɨɥɶɧɨɟ ɪɚɫɳɟɩɥɟɧɢɟ
ɮɪɭɤɬɨɡɨ-1,6-ɛɢɫɮɨɫɮɚɬɚ ɫ ɨɛɪɚɡɨɜɚɧɢɟɦ
ɞɢɝɢɞɪɨɤɫɢɚɰɟɬɨɧɮɨɫɮɚɬɚ ɢ ɝɥɢɰɟɪɚɥɶɞɟɝɢɞ-3-ɮɨɫɮɚɬɚ. Ɏɟɪɦɟɧɬ ɫɜɹɡɵɜɚɟɬɫɹ ɫ
ɮɪɭɤɬɨɡɨ-1,6-ɛɢɫɮɨɫɮɚɬɨɦ ɜ ɮɨɪɦɟ ɤɟɬɨɡɵ
ɫ ɧɟɡɚɦɤɧɭɬɨɣ ɰɟɩɶɸ, ɬɟ. ɩɪɨɢɫɯɨɞɢɬ ɟɝɨ
ɞɟɰɢɤɥɢɡɚɰɢɹ. Ɏɭɪɚɧɨɡɧɨɟ ɤɨɥɶɰɨ Dɚɧɨɦɟɪɚ ɫɩɨɧɬɚɧɧɨ ɨɬɤɪɵɜɚɟɬɫɹ ɢ ɡɚɤɪɵɜɚɟɬɫɹ 8 ɪɚɡ ɜ ɫɟɤɭɧɞɭ, ɜ ɬɨ ɜɪɟɦɹ ɤɚɤ ɰɢɤɥ ɜɚɧɨɦɟɪɚ ɨɬɤɪɵɜɚɟɬɫɹ ɢ ɡɚɤɪɵɜɚɟɬɫɹ 35 ɪɚɡ
ɜ ɫɟɤɭɧɞɭ. ȼ ɫɬɚɰɢɨɧɚɪɧɨɦ ɫɨɫɬɨɹɧɢɢ ɫɨɞɟɪɠɢɬɫɹ 81% Eɮɨɪɦɵ, 15% Dɮɨɪɦɵ,
1,5% ɝɟɦɞɢɨɥɚ ɢ 2% ɤɟɬɨɧɚ, ɧɨ ɤɨɥɢɱɟɫɬɜɨ
ɩɨɫɥɟɞɧɟɝɨ ɞɨɫɬɚɬɨɱɧɨ ɞɥɹ ɩɨɞɞɟɪɠɚɧɢɹ
ɦɚɤɫɢɦɚɥɶɧɨɣ ɫɤɨɪɨɫɬɢ ɮɟɪɦɟɧɬɚɬɢɜɧɨɝɨ
ɩɪɨɰɟɫɫɚ.
ʋ1x 2008 i ɬɨɦ 16
CH2OPO 32-
2-
CH2OPO3
OH
O
H
OH
C O
HO C H
H C
CH2OPO 32-
H
OH
OH
H C OH
H
CH2OPO 32Ɏɪɭɤɬɨɡɨ-1,6-ɛɢɫɮɨɫɮɚɬ
ɚɰɢɤɥɢɱɟɫɤɚɹ ɮɨɪɦɚ)
Ɏɪɭɤɬɨɡɨ-1,6-ɛɢɫɮɨɫɮɚɬ
ɰɢɤɥɢɱɟɫɤɚɹ ɮɭɪɚɧɨɡɧɚɹ
ɮɨɪɦɚ)
CH 2 OPO 3 2C
O
HO
C
H
H
C
OH
H
C
OH
O
C H
CH 2OH
Ɏɪɭɤɬɨɡɨɛɢɫɮɨɫɮɚɬɚɥɶɞɨɥɚɡɚ
CH 2 OPO 3 2Ɏɪɭɤɬɨɡɨ-1,6-ɛ ɢɫɮɨɫɮɚɬ
C
O
+
HC
OH
CH 2OPO 3 2-
CH 2 OPO 3 2-
Ⱦɢɝɢɞɪɨɤɫɢɚɰɟɬɨɧɮɨɫɮɚɬ
Ƚɥɢɰɟɪɚɥɶɞɟɝɢɞ-3-ɮɨɫɮɚɬ
Ɋɟɚɤɰɢɹ ɩɪɨɬɟɤɚɟɬ ɫ ɪɚɡɪɵɜɨɦ ɋ3±ɋ4
ɫɜɹɡɢ ɢ ɨɩɪɟɞɟɥɹɟɬ ɞɚɥɶɧɟɣɲɟɟ ɬɟɱɟɧɢɟ
ɝɥɢɤɨɥɢɡɚ. Ɋɚɜɧɨɜɟɫɢɟ ɪɟɚɤɰɢɢ ɫɢɥɶɧɨ
ɫɞɜɢɧɭɬɨ ɜ ɫɬɨɪɨɧɭ ɨɛɪɚɡɨɜɚɧɢɹ ɮɪɭɬɨɡɨ1,6-ɛɢɫɮɨɫɮɚɬɚ, ɧɨ ɞɚɥɶɧɟɣɲɟɟ ɨɤɢɫɥɟɧɢɟ
ɝɥɢɰɟɪɚɥɶɞɟɝɢɞ-3-ɮɨɫɮɚɬɚ ɩɨɞ ɜɨɡɞɟɣɫɬɜɢɟɦ ɝɥɢɰɟɪɚɥɶɞɟɝɢɞ-3-ɮɨɫɮɚɬɞɟɝɢɞɪɨɝɟɧɚɡɵ
ɫɞɜɢɝɚɟɬ ɪɟɚɤɰɢɹ ɜ ɫɬɨɪɨɧɭ ɨɛɪɚɡɨɜɚɧɢɹ
ɬɪɢɨɡɨɮɨɫɮɚɬɨɜ.
Ɉɬɫɭɬɫɬɜɢɟ ɢɥɢ ɞɟɮɢɰɢɬ ɤɢɫɥɨɪɨɞɚ ɜ
ɚɧɚɷɪɨɛɧɵɯ ɭɫɥɨɜɢɹɯ ɧɟ ɩɨɡɜɨɥɹɟɬ ɩɪɨɢɫɯɨɞɢɬɶ ɨɤɢɫɥɟɧɢɸ NADH ɜ ɞɵɯɚɬɟɥɶɧɨɣ
ɰɟɩɢ ɬɪɚɧɫɩɨɪɬɚ ɷɥɟɤɬɪɨɧɨɜ, ɨɛɪɚɡɨɜɚɜɲɟɝɨɫɹ ɜ ɝɥɢɰɟɪɚɥɶɞɟɝɢɞɞɟɝɢɞɪɨɝɟɧɚɡɧɨɣ ɪɟɚɤɰɢɢ. NAD+ ɹɜɥɹɟɬɫɹ ɧɟɨɛɯɨɞɢɦɵɦ ɤɨɦɩɨɧɟɧɬɨɦ ɞɥɹ ɞɚɥɶɧɟɣɲɟɝɨ ɨɤɢɫɥɟɧɢɹ ɝɥɢɰɟɪɚɥɶɞɟɝɢɞ-3-ɮɨɫɮɚɬɚ ɜ ɚɧɚɷɪɨɛɧɵɯ ɭɫɥɨɜɢɹɯ. Ɉɤɢɫɥɟɧɢɟ NADH ɨɛɟɫɩɟɱɢɜɚɟɬ ɥɚɤɬɚɬɞɟɝɢɞɪɨɝɟɧɚɡɚ. Ɋɟɚɤɰɢɹ ɩɪɨɬɟɤɚɟɬ ɩɨ
ɭɪɚɜɧɟɧɢɸ:
CH 3
CH 3
+ NADH+H +
HO
C ɇ + NAD +
C O ɥɚɤɬɚɬɞɟɝɢɞɪɨɝɟɧɚɡɚ
COO
COO
ɉɢɪɭɜɚɬ
L-Ʌɚɤɬɚɬ
ɍɫɬɚɧɨɜɥɟɧɨ, ɱɬɨ ɚɤɬɢɜɧɨɫɬɶ ɚɥɶɞɨɥɚɡɵ ɢ ɝɥɸɤɨɡɨɮɨɫɮɚɬɢɡɨɦɟɪɚɡɵ ɦɨɠɟɬ ɡɧɚɱɢɬɟɥɶɧɨ ɭɜɟɥɢɱɢɜɚɬɶɫɹ ɭ ɤɪɵɫ ɫ ɩɪɢɜɢɬɨɣ
ɫɚɪɤɨɦɨɣ 256 Walker, ɨɞɧɚɤɨ ɞɚɧɧɨɟ ɩɨɜɵɲɟɧɢɟ ɩɪɨɹɜɥɹɟɬɫɹ ɩɪɢ ɞɨɫɬɚɬɨɱɧɨ ɛɨɥɶɲɨɣ ɦɚɫɫɟ ɨɩɭɯɨɥɢ.
Ɋɚɤ ɦɨɥɨɱɧɨɣ ɠɟɥɟɡɵ ɡɚɧɢɦɚɟɬ ɨɞɧɨ
ɢɡ ɩɟɪɜɵɯ ɦɟɫɬ ɜ ɫɬɪɭɤɬɭɪɟ ɨɧɤɨɥɨɝɢɱɟɫɤɨɣ ɡɚɛɨɥɟɜɚɟɦɨɫɬɢ ɢ ɫɦɟɪɬɧɨɫɬɢ ɠɟɧɫɤɨɝɨ
ɧɚɫɟɥɟɧɢɹ. Ⱦɨ ɧɚɫɬɨɹɳɟɝɨ ɜɪɟɦɟɧɢ ɧɟ ɜɵɩɨɥɧɟɧɨ ɨɤɨɧɱɚɬɟɥɶɧɨɟ ɢɫɫɥɟɞɨɜɚɧɢɟ ɨɛɦɟɧɚ ɭɝɥɟɜɨɞɨɜ ɤɥɟɬɨɤ ɪɚɤɚ ɦɨɥɨɱɧɨɣ ɠɟɥɟɡɵ ɢ ɫɜɹɡɶ ɟɝɨ ɫ ɨɫɨɛɟɧɧɨɫɬɹɦɢ ɬɟɱɟɧɢɹ
ɡɚɛɨɥɟɜɚɧɢɹ.
ɐɟɥɶɸ ɞɚɧɧɨɝɨ ɢɫɫɥɟɞɨɜɚɧɢɹ ɛɵɥɨ ɢɡɭɱɢɬɶ ɦɟɬɚɛɨɥɢɱɟɫɤɭɸ ɚɤɬɢɜɧɨɫɬɶ ɝɥɢɤɨɥɢɡɚ ɜ ɫɵɜɨɪɨɬɤɟ ɤɪɨɜɢ ɛɨɥɶɧɵɯ ɪɚɤɨɦ ɦɨɥɨɱɧɨɣ ɠɟɥɟɡɵ ɫ ɪɚɡɥɢɱɧɨɣ ɪɚɫɩɪɨɫɬɪɚɧɟɧɧɨɫɬɶɸ ɡɚɛɨɥɟɜɚɧɢɹ.
Ɇɚɬɟɪɢɚɥɵ ɢ ɦɟɬɨɞɵ
ȼ ɩɪɨɫɩɟɤɬɢɜɧɨɦ ɢɫɫɥɟɞɨɜɚɧɢɢ ɨɛɫɥɟɞɨɜɚɧɵ 90 ɛɨɥɶɧɵɯ ɪɚɤɨɦ ɦɨɥɨɱɧɨɣ
ɠɟɥɟɡɵ, ɩɪɨɯɨɞɢɜɲɢɯ ɥɟɱɟɧɢɟ ɜ ȼɢɬɟɛɫɤɨɦ ɨɛɥɚɫɬɧɨɦ ɨɧɤɨɥɨɝɢɱɟɫɤɨɦ ɞɢɫɩɚɧɫɟɪɟ ɜ 2006-2007 ɝɝ. ɢ 16 ɡɞɨɪɨɜɵɯ ɞɨɧɨɪɨɜ.
Ʉɪɢɬɟɪɢɟɦ ɜɤɥɸɱɟɧɢɹ ɜ ɢɫɫɥɟɞɨɜɚɧɢɟ
ɹɜɢɥɨɫɶ ɧɚɥɢɱɢɟ ɰɢɬɨɥɨɝɢɱɟɫɤɢ ɢɥɢ ɝɢɫɬɨɥɨɝɢɱɟɫɤɢ ɜɟɪɢɮɢɰɢɪɨɜɚɧɧɨɝɨ ɪɚɤɚ ɦɨɥɨɱɧɨɣ ɠɟɥɟɡɵ, ɨɬɫɭɬɫɬɜɢɟ ɩɨɪɚɠɟɧɢɹ ɩɟɱɟɧɢ ɦɟɬɚɫɬɚɬɢɱɟɫɤɢɦ ɥɢɛɨ ɧɟɫɩɟɰɢɮɢɱɟɫɤɢɦ ɩɪɨɰɟɫɫɨɦ ɩɨ ɞɚɧɧɵɦ ɍɁɂ, ɧɨɪɦɚɥɶɧɵɟ ɩɨɤɚɡɚɬɟɥɢ ɛɢɥɢɪɭɛɢɧɚ, ȺɥȺɌ,
ȺɫȺɌ ɩɪɢ ɛɢɨɯɢɦɢɱɟɫɤɨɦ ɢɫɫɥɟɞɨɜɚɧɢɢ
ɫɵɜɨɪɨɬɤɢ ɤɪɨɜɢ. ȼ ɩɥɚɧɟ ɢɫɫɥɟɞɨɜɚɧɢɹ
ɜɵɞɟɥɹɥɢ ɫɥɟɞɭɸɳɢɟ ɝɪɭɩɩɵ ɛɨɥɶɧɵɯ ɩɨ
ɫɬɚɞɢɹɦ ɫɨɝɥɚɫɧɨ ɩɪɢɤɚɡɭ ʋ80 ɨɬ 9 ɮɟɜɪɚɥɹ 2007 ɝ. ɨɛ ɭɬɜɟɪɠɞɟɧɢɢ ɤɥɢɧɢɱɟɫɤɢɯ
ɩɪɨɬɨɤɨɥɨɜ «Ⱥɥɝɨɪɢɬɦɵ ɞɢɚɝɧɨɫɬɢɤɢ ɢ ɥɟɱɟɧɢɹ ɛɨɥɶɧɵɯ ɡɥɨɤɚɱɟɫɬɜɟɧɧɵɦɢ ɧɨɜɨɨɛɪɚɡɨɜɚɧɢɹɦɢ»:
1) ɛɨɥɶɧɵɟ ɫ 1-ɨɣ ɫɬɚɞɢɟɣ ɪɚɤɚ ɦɨɥɨɱɧɨɣ ɠɟɥɟɡɵ (T1N0M0);
2) ɛɨɥɶɧɵɟ ɫɨ 2-ɨɣ ɫɬɚɞɢɟɣ ɪɚɤɚ ɦɨɥɨɱ91
” ɇɨɜɨɫɬɢ ɯɢɪɭɪɝɢɢ
ɧɨɣ ɠɟɥɟɡɵ (T 0N 1M 0, T 1N 1M 0, T 2N 0M 0,
T2N1M0, T3N0M0);
3) ɛɨɥɶɧɵɟ ɫ 3-ɟɣ ɫɬɚɞɢɟɣ ɪɚɤɚ ɦɨɥɨɱɧɨɣ ɠɟɥɟɡɵ (T 0N 2M 0, T 1N 2M 0, T 2N 2M 0,
T0N1M0, T3N1M0, T3N2M0, T4N0M0, T4N1M0,
T4N2M0, TɥɸɛɚɹN3M0);
4) ɛɨɥɶɧɵɟ ɫ 4-ɨɣ ɫɬɚɞɢɟɣ ɪɚɤɚ ɦɨɥɨɱɧɨɣ ɠɟɥɟɡɵ (TɥɸɛɚɹNɥɸɛɚɹM1).
ȼɟɧɨɡɧɭɸ ɤɪɨɜɶ ɩɨɥɭɱɚɥɢ ɩɪɢ ɜɟɧɟɩɭɧɤɰɢɢ ɧɚɬɨɳɚɤ ɢ ɩɟɪɟɧɨɫɢɥɢ ɜ ɫɭɯɭɸ ɩɪɨɛɢɪɤɭ. ɉɨɫɥɟ ɪɟɬɪɚɤɰɢɢ ɫɝɭɫɬɤɚ ɩɪɨɜɨɞɢɥɢ
ɰɟɧɬɪɢɮɭɝɢɪɨɜɚɧɢɟ ɩɪɢ 1500 ɨɛɦɢɧ ɜ ɬɟɱɟɧɢɟ 15 ɦɢɧ. ɉɨɥɭɱɟɧɧɭɸ ɫɵɜɨɪɨɬɤɭ, ɧɟ
ɢɦɟɸɳɭɸ ɩɪɢɡɧɚɤɨɜ ɝɟɦɨɥɢɡɚ, ɞɟɥɢɥɢ ɧɚ
ɚɥɢɤɜɨɬɵ ɢ ɡɚɦɨɪɚɠɢɜɚɥɢ ɜ ɧɢɡɤɨɬɟɦɩɟɪɚɬɭɪɧɨɣ ɯɨɥɨɞɢɥɶɧɨɣ ɭɫɬɚɧɨɜɤɟ ɩɪɢ –1618°ɋ, ɝɞɟ ɯɪɚɧɢɥɢ ɞɨ ɢɫɫɥɟɞɨɜɚɧɢɹ. Ɉ ɦɟɬɚɛɨɥɢɱɟɫɤɨɣ ɚɤɬɢɜɧɨɫɬɢ ɝɥɢɤɨɥɢɡɚ ɫɭɞɢɥɢ ɩɨ ɢɡɦɟɧɟɧɢɸ ɤɚɬɚɥɢɬɢɱɟɫɤɨɣ ɚɤɬɢɜɧɨɫɬɢ ɮɟɪɦɟɧɬɨɜ: ɥɚɤɬɚɬɞɟɝɢɞɪɨɝɟɧɚɡɵ, ɮɪɭɤɬɨɡɨ-1,6-ɛɢɫɮɨɫɮɚɬɚɥɶɞɨɥɚɡɵ, ɝɥɸɤɨɡɨɮɨɫɮɚɬɢɡɨɦɟɪɚɡɵ. Ⱥɤɬɢɜɧɨɫɬɶ ɥɚɤɬɚɬɞɟɝɢɞɪɨɝɟɧɚɡɵ ɨɩɪɟɞɟɥɹɥɢ ɜ ɫɵɜɨɪɨɬɤɟ ɤɪɨɜɢ ɩɨ
ɦɟɬɨɞɭ Howell [7] ɢ ɜɵɪɚɠɚɥɢ ɜ ɧɦɨɥɶÂɫ-1Âɥ-1.
Ⱥɤɬɢɜɧɨɫɬɶ ɮɪɭɤɬɨɡɨ-1,6-ɛɢɫɮɨɫɮɚɬɚɥɶɞɨɥɚɡɵ ɨɩɪɟɞɟɥɹɥɢ ɩɨ Bruns. Ⱥɤɬɢɜɧɨɫɬɶ ɜ
ɫɵɜɨɪɨɬɤɟ ɤɪɨɜɢ ɝɥɸɤɨɡɨɮɨɫɮɚɬɢɡɨɦɟɪɚɡɵ
ɨɩɪɟɞɟɥɹɥɢ ɩɨ ɦɟɬɨɞɭ Bruns ɢ Hinsberg [8].
ɉɨɥɭɱɟɧɧɵɟ ɞɚɧɧɵɟ ɨɛɪɚɛɚɬɵɜɚɥɢ ɫɬɚɬɢɫɬɢɱɟɫɤɢ. Ɋɚɫɫɱɢɬɵɜɚɥɢ ɦɟɞɢɚɧɭ (Ɇ), ɫɪɟɞɧɟɟ ɤɜɚɞɪɚɬɢɱɟɫɤɨɟ ɨɬɤɥɨɧɟɧɢɟ (V), ɜɟɪɯɧɢɣ
ɢ ɧɢɠɧɢɣ ɤɜɚɪɬɢɥɢ. ɉɪɢ ɨɰɟɧɤɟ ɞɨɫɬɨɜɟɪɧɨɫɬɢ ɢɡɦɟɧɟɧɢɣ ɢɫɯɨɞɢɥɢ ɢɡ ɝɢɩɨɬɟɡɵ ɨ
ɧɟɝɚɭɫɫɨɜɨɦ ɪɚɫɩɪɟɞɟɥɟɧɢɢ ɭɱɟɬɧɨɝɨ ɩɪɢɡɧɚɤɚ ɜ ɢɡɭɱɚɟɦɵɯ ɝɪɭɩɩɚɯ. Ⱦɥɹ ɨɰɟɧɤɢ ɡɧɚɱɢɦɨɫɬɢ ɢɡɦɟɧɟɧɢɣ ɦɟɠɞɭ ɝɪɭɩɩɚɦɢ ɢɫɩɨɥɶɡɨɜɚɥɢ ɤɪɢɬɟɪɢɣ Ɇɚɧɧɚ±ɍɢɬɧɢ, Ʉɪɚɫɤɟɥɥɚ±ɍɨɥɥɟɫɚ. ɂɡɦɟɧɟɧɢɹ ɫɱɢɬɚɥɢ ɞɨɫɬɨɜɟɪɧɵɦɢ ɩɪɢ ɪ<0,05.
Ɋɟɡɭɥɶɬɚɬɵ ɢ ɨɛɫɭɠɞɟɧɢɟ
ɍɫɬɚɧɨɜɥɟɧɨ, ɱɬɨ ɚɤɬɢɜɧɨɫɬɶ ɥɚɤɬɚɬɞɟɝɢɞɪɨɝɟɧɚɡɵ ɜ ɫɵɜɨɪɨɬɤɟ ɤɪɨɜɢ ɛɨɥɶɧɵɯ
ɪɚɤɨɦ ɦɨɥɨɱɧɨɣ ɠɟɥɟɡɵ (n=90) ɫɨɫɬɚɜɢɥɚ
92
485,77 ɧɦɨɥɶÂɫ-1Âɥ-1 (V=193,95) ɢ ɛɵɥɚ ɜɵɲɟ,
ɱɟɦ ɭ ɡɞɨɪɨɜɵɯ ɞɨɧɨɪɨɜ 384,75 ɧɦɨɥɶÂɫ-1Âɥ-1
(V=87,22, n=16), ɬɟɫɬ Ɇɚɧɧɚ±ɍɢɬɧɢ
p=0,0134. ɍ ɛɨɥɶɧɵɯ 1 ɫɬɚɞɢɟɣ ɪɚɤɚ ɦɨɥɨɱɧɨɣ ɠɟɥɟɡɵ ɚɤɬɢɜɧɨɫɬɶ ɥɚɤɬɚɬɞɟɝɢɞɪɨɝɟɧɚɡɵ ɛɵɥɚ 504,93 ɧɦɨɥɶÂɫ-1Âɥ-1 (V=192,64), ɱɬɨ
ɞɨɫɬɨɜɟɪɧɨ ɜɵɲɟ (ɬɟɫɬ Ɇɚɧɧɚɍɢɬɧɢ
p=0,0125), ɱɟɦ ɭ ɞɨɧɨɪɨɜ. ɉɨɞɨɛɧɚɹ ɤɚɪɬɢɧɚ ɧɚɛɥɸɞɚɥɚɫɶ ɢ ɩɪɢ 2-ɨɣ ɫɬɚɞɢɢ ɪɚɤɚ
ɦɨɥɨɱɧɨɣ ɠɟɥɟɡɵ, ɝɞɟ ɚɤɬɢɜɧɨɫɬɶ ɥɚɤɬɚɬɞɟɝɢɞɪɨɝɟɧɚɡɵ ɫɨɫɬɚɜɥɹɥɚ 514,83 ɧɦɨɥɶÂɫ-1Âɥ-1
(V=181,62), ɱɬɨ ɞɨɫɬɨɜɟɪɧɨ ɜɵɲɟ, ɱɟɦ ɭ ɞɨɧɨɪɨɜ (ɬɟɫɬ Ɇɚɧɧɚɍɢɬɧɢ p=0,00549). ɉɪɢ
3-ɟɣ ɫɬɚɞɢɢ ɪɚɤɚ ɦɨɥɨɱɧɨɣ ɠɟɥɟɡɵ ɚɤɬɢɜɧɨɫɬɶ ɥɚɤɬɚɬɞɟɝɢɞɪɨɝɟɧɚɡɵ ɛɵɥɚ ɜɵɲɟ, ɱɟɦ
ɭ ɞɨɧɨɪɨɜ ɧɚ 15,15% ɢ ɫɨɫɬɚɜɢɥɚ 443,09
ɧɦɨɥɶÂɫ-1Âɥ-1 (ɬɟɫɬ Ɇɚɧɧɚɍɢɬɧɢ p=0,25)
ɪɢɫ. 2).
Ⱥɤɬɢɜɧɨɫɬɶ ɮɪɭɤɬɨɡɨ-1,6-ɛɢɫɮɨɫɮɚɬɚɥɶɞɨɥɚɡɵ ɜ ɝɪɭɩɩɟ ɛɨɥɶɧɵɯ ɪɚɤɨɦ ɦɨɥɨɱɧɨɣ ɠɟɥɟɡɵ 1-ɨɣ ɫɬɚɞɢɢ (n=27) ɫɨɫɬɚɜɢɥɚ
2,57 ɦɤɦɨɥɶÂɫ-1Âɥ-1 (V=0,84), ɜ ɝɪɭɩɩɟ ɛɨɥɶɧɵɯ ɪɚɤɨɦ ɦɨɥɨɱɧɨɣ ɠɟɥɟɡɵ 2-ɨɣ ɫɬɚɞɢɢ
(n=15) ɷɬɨɬ ɩɨɤɚɡɚɬɟɥɶ ɛɵɥ ɪɚɜɟɧ 2,94
ɦɤɦɨɥɶÂɫ-1Âɥ-1 (V=0,71), ɜ ɝɪɭɩɩɟ ɛɨɥɶɧɵɯ
ɪɚɤɨɦ ɦɨɥɨɱɧɨɣ ɠɟɥɟɡɵ 3-ɟɣ ɫɬɚɞɢɢ (n=20)
ɚɤɬɢɜɧɨɫɬɶ ɮɪɭɤɬɨɡɨ-1,6-ɛɢɫɮɨɫɮɚɬɚɥɶɞɨɥɚɡɵ ɫɨɫɬɚɜɢɥɚ 3,02 ɦɤɦɨɥɶÂɫ-1Âɥ-1 (V=0,57)
ɪɢɫ. 3).
Ɇɟɞɢɚɧɚ ɚɤɬɢɜɧɨɫɬɢ ɝɥɸɤɨɡɨɮɨɫɮɚɬɢɡɨɦɟɪɚɡɵ ɜ ɫɵɜɨɪɨɬɤɟ ɤɪɨɜɢ ɞɨɧɨɪɨɜ (n=16)
ɫɨɫɬɚɜɢɥɚ 123,72 ɧɦɨɥɶÂɫ-1Âɥ-1 (V=18,66). ɍ
ɛɨɥɶɧɵɯ ɫ 1-ɨɣ ɫɬɚɞɢɟɣ ɪɚɤɚ ɦɨɥɨɱɧɨɣ ɠɟɥɟɡɵ (n=34) ɚɤɬɢɜɧɨɫɬɶ ɝɥɸɤɨɡɨɮɨɫɮɚɬɢɡɨɦɟɪɚɡɵ ɛɵɥɚ ɩɨɜɵɲɟɧɚ ɜ 1,64 ɪɚɡɚ ɩɨ ɫɪɚɜɧɟɧɢɸ ɫ ɚɧɚɥɨɝɢɱɧɵɦ ɩɨɤɚɡɚɬɟɥɟɦ ɭ ɞɨɧɨɪɨɜ ɢ ɫɨɫɬɚɜɢɥɚ 202,58 ɧɦɨɥɶÂɫ -1 Âɥ -1
(V=61,31), ɢɡɦɟɧɟɧɢɹ ɞɨɫɬɨɜɟɪɧɵ, Ɍɟɫɬ
Ɇɚɧɧɚɍɢɬɧɢ ɪ=0,000015. Ɉɬɦɟɱɚɥɚɫɶ ɬɟɧɞɟɧɰɢɹ ɤ ɭɜɟɥɢɱɟɧɢɸ ɚɤɬɢɜɧɨɫɬɢ ȽɎɂ ɜ
ɫɵɜɨɪɨɬɤɟ ɤɪɨɜɢ ɛɨɥɶɧɵɯ ɪɚɤɨɦ ɦɨɥɨɱɧɨɣ
ɠɟɥɟɡɵ ɩɚɪɚɥɥɟɥɶɧɨ ɫ ɭɜɟɥɢɱɟɧɢɟɦ ɫɬɚɞɢɢ
ɡɚɛɨɥɟɜɚɧɢɹ. ȼ ɝɪɭɩɩɟ ɛɨɥɶɧɵɯ 2-ɨɣ ɫɬɚɞɢɟɣ ɊɆɀ (n=30) ɚɤɬɢɜɧɨɫɬɶ ɝɥɸɤɨɡɨɮɨɫɮɚɬɢɡɨɦɟɪɚɡɵ ɛɵɥɚ ɜɵɲɟ ɢ ɫɨɫɬɚɜɢɥɚ
ʋ1x 2008 i ɬɨɦ 16
900
800
700
600
500
ɧɤɚɬ
400
300
200
100
Median
25%-75%
Min-Max
0
0
1
2
3
Ƚɪɭɩɩɵ
Ɋɢɫ. 2. Ⱥɤɬɢɜɧɨɫɬɶ ɥɚɤɬɚɬɞɟɝɢɞɪɨɝɟɧɚɡɵ ɜ ɫɵɜɨɪɨɬɤɟ ɤɪɨɜɢ ɛɨɥɶɧɵɯ ɪɚɤɨɦ ɦɨɥɨɱɧɨɣ ɠɟɥɟɡɵ 1-ɨɣ – 3ɟɣ ɫɬɚɞɢɣ ɢ ɡɞɨɪɨɜɵɯ ɞɨɧɨɪɨɜ.
4,2
4,0
3,8
3,6
3,4
3,2
3,0
2,8
2,6
ɧɤɚɬ
2,4
2,2
2,0
1,8
1,6
1,4
1,2
1,0
1
2
3
Median
25%-75%
Min-Max
ɋɬɚɞɢɹ
Ɋɢɫ. 3. Ⱥɤɬɢɜɧɨɫɬɶ ɮɪɭɤɬɨɡɨ-1,6-ɛɢɫɮɨɫɮɚɬɚɥɶɞɨɥɚɡɵ ɜ ɫɵɜɨɪɨɬɤɟ ɤɪɨɜɢ ɛɨɥɶɧɵɯ ɪɚɤɨɦ ɦɨɥɨɱɧɨɣ
ɠɟɥɟɡɵ 1-ɨɣ – 3-ɟɣ ɫɬɚɞɢɣ ɢ ɡɞɨɪɨɜɵɯ ɞɨɧɨɪɨɜ.
93
” ɇɨɜɨɫɬɢ ɯɢɪɭɪɝɢɢ
221,94 ɧɦɨɥɶÂɫ-1Âɥ-1 (V=80,30) ɬɟɫɬ Ɇɚɧɧɚɍɢɬɧɢ ɩɨ ɫɪɚɜɧɟɧɢɸ ɫ ɝɪɭɩɩɨɣ ɛɨɥɶɧɵɯ ɫ
1-ɨɣ ɫɬɚɞɢɟɣ ɪɚɤɚ ɦɨɥɨɱɧɨɣ ɠɟɥɟɡɵ ɪ=0,32.
Ⱥɤɬɢɜɧɨɫɬɶ ɝɥɸɤɨɡɨɮɨɫɮɚɬɢɡɨɦɟɪɚɡɵ ɭ
ɛɨɥɶɧɵɯ 3 ɫɬɚɞɢɟɣ ɪɚɤɚ ɦɨɥɨɱɧɨɣ ɠɟɥɟɡɵ
(n=24) ɧɚɛɥɸɞɚɥɢɫɶ ɛɥɢɡɤɢɟ ɡɧɚɱɟɧɢɹ ɫ ɬɚɤɨɜɵɦɢ ɜ ɝɪɭɩɩɟ ɛɨɥɶɧɵɯ ɫ 1-ɨɣ ɫɬɚɞɢɟɣ ɢ
2-ɨɣ ɫɬɚɞɢɟɣ ɊɆɀ. Ɇɟɞɢɚɧɚ ɫɨɫɬɚɜɢɥɚ
224,31 ɧɦɨɥɶÂɫ-1Âɥ-1 (V=93,46) ɬɟɫɬ Ɇɚɧɧɚɍɢɧɬɧɢ ɩɨ ɫɪɚɜɧɟɧɢɸ ɫ ɝɪɭɩɩɨɣ ɫɨ 2-ɨɣ
ɫɬɚɞɢɟɣ ɪɚɤɚ ɦɨɥɨɱɧɨɣ ɠɟɥɟɡɵ ɪ=0,71. ɍ
ɛɨɥɶɧɵɯ 4-ɨɣ ɫɬɚɞɢɟɣ ɪɚɤɚ ɦɨɥɨɱɧɨɣ ɠɟɥɟɡɵ ɧɚɛɥɸɞɚɥɨɫɶ ɛɨɥɟɟ ɡɧɚɱɢɬɟɥɶɧɨɟ ɩɨɜɵɲɟɧɢɟ ɚɤɬɢɜɧɨɫɬɢ ȽɎɂ ɞɨ 467,50
ɧɦɨɥɶÂɫ-1Âɥ-1 (V=6,68), ɬɟɫɬ Ɇɚɧɧɚ – ɍɢɬɧɢ
ɩɨ ɫɪɚɜɧɟɧɢɸ ɫ ɛɨɥɶɧɵɦɢ ɫ 3-ɟɣ ɫɬɚɞɢɟɣ
ɪɚɤɚ ɦɨɥɨɱɧɨɣ ɠɟɥɟɡɵ ɪ=0,02, ɢɡɦɟɧɟɧɢɹ
ɞɨɫɬɨɜɟɪɧɵ. ɋɥɟɞɭɟɬ ɨɬɦɟɬɢɬɶ, ɱɬɨ ɧɚɥɢɱɢɟ
ɡɥɨɤɚɱɟɫɬɜɟɧɧɨɣ ɨɩɭɯɨɥɢ ɨɩɪɟɞɟɥɹɥɨ ɡɧɚɱɢɬɟɥɶɧɨɟ ɩɨɜɵɲɟɧɢɟ ɚɤɬɢɜɧɨɫɬɢ ɝɥɸɤɨɡɨɮɨɫɮɚɬɢɡɨɦɟɪɚɡɵ, ɤɨɬɨɪɨɟ ɨɫɬɚɜɚɥɨɫɶ ɞɨɫɬɚɬɨɱɧɨ ɫɬɚɛɢɥɶɧɵɦ ɜ ɝɪɭɩɩɚɯ ɛɨɥɶɧɵɯ ɫ 1,2,3ɟɣ ɫɬɚɞɢɹɦɢ. ɍ ɛɨɥɶɧɵɯ ɫ 4-ɨɣ ɫɬɚɞɢɟɣ ɪɚɤɚ
ɦɨɥɨɱɧɨɣ ɠɟɥɟɡɵ ɧɚɛɥɸɞɚɥɚɫɶ ɦɚɤɫɢɦɚɥɶɧɚɹ ɚɤɬɢɜɧɨɫɬɶ ɝɥɸɤɨɡɨɮɨɫɮɚɬɢɡɨɦɟɪɚɡɵ.
Ⱦɥɹ ɨɰɟɧɤɢ ɫɨɨɬɧɨɲɟɧɢɹ ɦɟɬɚɛɨɥɢɱɟɫɤɨɣ ɚɤɬɢɜɧɨɫɬɢ ɪɚɡɥɢɱɧɵɯ ɫɬɚɞɢɣ ɝɥɢɤɨɥɢ-
ɡɚ ɜɵɩɨɥɧɹɥɢ ɪɚɫɱɟɬɵ ɨɬɧɨɫɢɬɟɥɶɧɵɯ ɤɨɷɮɮɢɰɢɟɧɬɨɜ ɚɤɬɢɜɧɨɫɬɟɣ ɢɡɭɱɟɧɧɵɯ ɮɟɪɦɟɧɬɨɜ, ɪɟɡɭɥɶɬɚɬɵ ɤɨɬɨɪɵɯ ɩɪɟɞɫɬɚɜɥɟɧɵ
ɜ ɬɚɛɥɢɰɟ 1.
ɂɫɫɥɟɞɨɜɚɧɢɟ ɫɨɨɬɧɨɲɟɧɢɣ ɚɤɬɢɜɧɨɫɬɢ ɮɟɪɦɟɧɬɨɜ ɝɥɢɤɨɥɢɡɚ ɩɨɤɚɡɚɥɨ, ɱɬɨ ɚɤɬɢɜɧɨɫɬɶ ɮɪɭɤɬɨɡɨ-1,6-ɛɢɫɮɨɫɮɚɬɚɥɶɞɨɥɚɡɵ
ɡɧɚɱɢɬɟɥɶɧɨ ɩɪɟɜɨɫɯɨɞɢɬ ɚɤɬɢɜɧɨɫɬɶ ɝɥɸɤɨɡɨɮɨɫɮɚɬɢɡɨɦɟɪɚɡɵ ɢ ɥɚɤɬɚɬɞɟɝɢɞɪɨɝɟɧɚɡɵ,
ɚ ɚɤɬɢɜɧɨɫɬɶ ɥɚɤɬɚɬɞɟɝɢɞɪɨɝɟɧɚɡɵ ɩɪɟɜɨɫɯɨɞɢɬ ɚɤɬɢɜɧɨɫɬɶ ɝɥɸɤɨɡɨɮɨɫɮɚɬɢɡɨɦɟɪɚɡɵ.
ɗɬɨ ɦɨɠɟɬ ɜɵɡɵɜɚɬɶ ɨɛɪɚɡɨɜɚɧɢɟ ɢɡɛɵɬɤɚ
ɬɪɢɨɡɨɮɨɫɮɚɬɨɜ ɜ ɚɥɶɞɨɥɚɡɧɨɣ ɪɟɚɤɰɢɢ, ɱɬɨ,
ɜɟɪɨɹɬɧɨ, ɜɵɡɵɜɚɟɬ ɛɨɥɟɟ ɚɤɬɢɜɧɵɣ ɦɟɬɚɛɨɥɢɡɦ ɝɥɢɰɟɪɚɥɶɞɟɝɢɞ-3-ɮɨɫɮɚɬɚ ɩɨ ɧɟɨɤɢɫɥɢɬɟɥɶɧɨɦɭ ɩɟɧɬɨɡɨɮɨɫɮɚɬɧɨɦɭ ɩɭɬɢ.
ɋɨɨɬɧɨɲɟɧɢɟ ɥɚɤɬɚɬɞɟɝɢɞɪɨɝɟɧɚɡɵ ɢ
ɝɥɸɤɨɡɨɮɨɫɮɚɬɢɡɨɦɟɪɚɡɵ ɭɦɟɧɶɲɚɟɬɫɹ ɫ
ɭɜɟɥɢɱɟɧɢɟɦ ɫɬɚɞɢɢ ɡɚɛɨɥɟɜɚɧɢɹ. ɗɬɨ ɦɨɠɟɬ ɫɜɢɞɟɬɟɥɶɫɬɜɨɜɚɬɶ ɨ ɛɨɥɶɲɟɣ ɷɤɫɩɪɟɫɫɢɢ ɝɥɸɤɨɡɨɮɨɫɮɚɬɢɡɨɦɟɪɚɡɵ ɜ ɨɩɭɯɨɥɟɜɵɯ
ɤɥɟɬɤɚɯ, ɚ ɩɨɫɤɨɥɶɤɭ ɜɨ 2-ɨɣ, 3-ɟɣ ɫɬɚɞɢɹɯ
ɱɚɫɬɨ ɞɢɚɝɧɨɫɰɢɪɭɸɬɫɹ ɨɩɭɯɨɥɢ ɫ ɚɝɪɟɫɫɢɜɧɵɦ ɮɟɧɨɬɢɩɨɦ, ɬɨ ɦɨɠɧɨ ɫɞɟɥɚɬɶ ɩɪɟɞɩɨɥɨɠɟɧɢɟ ɨ ɫɜɹɡɢ ɚɝɪɟɫɫɢɜɧɨɝɨ ɮɟɧɨɬɢɩɚ
ɨɩɭɯɨɥɟɣ ɢ ɫɬɟɩɟɧɶɸ ɷɤɫɩɪɟɫɫɢɢ ɝɥɸɤɨɡɨɮɨɫɮɚɬɢɡɨɦɟɪɚɡɵ.
Ɍɚɛɥɢɰɚ 1
ɋɨɨɬɧɨɲɟɧɢɟ ɚɤɬɢɜɧɨɫɬɟɣ ɮɟɪɦɟɧɬɨɜ ɝɥɢɤɨɥɢɡɚ ɜ ɫɵɜɨɪɨɬɤɟ ɤɪɨɜɢ ɛɨɥɶɧɵɯ
ɨɩɟɪɚɛɟɥɶɧɵɦ ɪɚɤɨɦ ɦɨɥɨɱɧɨɣ ɠɟɥɟɡɵ
ɋɨɨɬɧɨɲɟɧɢɟ ɚɤɬɢɜɧɨɫɬɟɣ
ɮɟɪɦɟɧɬɨɜ
Ɏɪɭɤɬɨɡɨ-1,6ɛɢɫɮɨɫɮɚɬɚɥɶɞɨɥɚɡɚ /
ɝɥɸɤɨɡɨɮɨɫɮɚɬɢɡɨɦɟɪɚɡɚ
Ɏɪɭɤɬɨɡɨ-1,6ɛɢɫɮɨɫɮɚɬɚɥɶɞɨɥɚɡɚ /
ɥɚɤɬɚɬɞɟɝɢɞɪɨɝɟɧɚɡɚ
Ʌɚɤɬɚɬɞɟɝɢɞɪɨɝɟɧɚɡɚ /
ɝɥɸɤɨɡɨɮɨɫɮɚɬɢɡɨɦɟɪɚɡɚ
* – % ɫɨɨɬɧɨɲɟɧɢɟ ɤ 1-ɨɣ ɫɬɚɞɢɢ
94
1-ɹ ɫɬɚɞɢɹ
2-ɹ ɫɬɚɞɢɹ
3-ɹ ɫɬɚɞɢɹ
12,69
(100,00%)*
13,25
(104,41%)
13,46
(106,07%)
5,09
(100%)
5,68
(111,59%)
6,82
(133,99%)
2,49
(100%)
2,33
(93,57%)
1,97
(79,12%)
ʋ1x 2008 i ɬɨɦ 16
ȼɵɜɨɞɵ
ɅɂɌȿɊȺɌɍɊȺ
1. Ⱥɤɬɢɜɧɨɫɬɶ ɥɚɤɬɚɬɞɟɝɢɞɪɨɝɟɧɚɡɵ ɜ
ɫɵɜɨɪɨɬɤɟ ɤɪɨɜɢ ɛɨɥɶɧɵɯ ɪɚɤɨɦ ɦɨɥɨɱɧɨɣ
ɠɟɥɟɡɵ ɫɨɫɬɚɜɢɥɚ 485,77 ɧɦɨɥɶÂɫ -1Âɥ -1
(V=193,95), ɢ ɛɵɥɚ ɧɚ 26,26% ɜɵɲɟ, ɱɟɦ ɭ
ɡɞɨɪɨɜɵɯ ɞɨɧɨɪɨɜ.
2. Ⱥɤɬɢɜɧɨɫɬɶ ɝɥɸɤɨɡɨɮɨɫɮɚɬɢɡɨɦɟɪɚɡɵ
ɭ ɛɨɥɶɧɵɯ ɪɚɤɨɦ ɦɨɥɨɱɧɨɣ ɠɟɥɟɡɵ 1-ɨɣ ɫɬɚɞɢɢ ɛɵɥɚ ɩɨɜɵɲɟɧɚ ɜ 1,64 ɪɚɡɚ ɩɨ ɫɪɚɜɧɟɧɢɸ ɫ ɚɧɚɥɨɝɢɱɧɵɦ ɩɨɤɚɡɚɬɟɥɟɦ ɭ ɞɨɧɨɪɨɜ
ɢ ɫɨɫɬɚɜɢɥɚ 202,58 ɧɦɨɥɶÂɫ-1Âɥ-1 (V=61,31).
3. Ɉɬɦɟɱɟɧɚ ɬɟɧɞɟɧɰɢɹ ɤ ɭɜɟɥɢɱɟɧɢɸ
ɚɤɬɢɜɧɨɫɬɢ ɮɪɭɤɬɨɡɨ-1,6-ɛɢɫɮɨɫɮɚɬɚɥɶɞɨɥɚɡɵ ɜ ɫɵɜɨɪɨɬɤɟ ɤɪɨɜɢ ɛɨɥɶɧɵɯ ɨɩɟɪɚɛɟɥɶɧɵɦ ɪɚɤɨɦ ɦɨɥɨɱɧɨɣ ɠɟɥɟɡɵ 1-ɨɣ – 3ɟɣ ɫɬɚɞɢɢ.
4. ɍɦɟɧɶɲɟɧɢɟ ɫɨɨɬɧɨɲɟɧɢɹ ɚɤɬɢɜɧɨɫɬɢ ɥɚɤɬɚɬɞɟɝɢɞɪɨɝɟɧɚɡɵ ɢ ɝɥɸɤɨɡɨɮɨɫɮɚɬɢɡɨɦɟɪɚɡɵ ɩɪɢ ɭɜɟɥɢɱɟɧɢɢ ɫɬɚɞɢɢ ɡɚɛɨɥɟɜɚɧɢɹ ɦɨɠɟɬ ɫɜɢɞɟɬɟɥɶɫɬɜɨɜɚɬɶ ɨ ɛɨɥɶɲɟɣ ɷɤɫɩɪɟɫɫɢɢ ɝɥɸɤɨɡɨɮɨɫɮɚɬɢɡɨɦɟɪɚɡɵ ɜ
ɨɩɭɯɨɥɟɜɵɯ ɤɥɟɬɤɚɯ ɢ, ɜɨɡɦɨɠɧɨ, ɫɜɹɡɚɧɨ ɫ
ɚɝɪɟɫɫɢɜɧɵɦ ɮɟɧɨɬɢɩɨɦ ɨɩɭɯɨɥɢ.
1. Warburg, O. H. Ueber den stoffwechsel der tumoren
/ O. H. Warburg. – Berlin: Springer, 1926. – 263 p.
2. The metabolism of tumours: 70 years later / G. L.
Semenza [et al.] // Novartis Found. Symp. – 2001. – Vol.
240. – P. 251-260.
3. Czernin, J. Positron emission tomography scanning:
current and future applications / J. Czernin, M. E. Phelps
// Annu. Rev. Med. – 2002. – Vol. 53. – P. 89-112.
4. Biologic correlates of 18fluorodeoxyglucose uptake
in human breast cancer measured by positron emission
tomography / R. Bos [et al.] // J. Clin. Oncol. – 2002. –
Vol. 20. – P. 379-387.
5. Overexpression of Glut-1 and increased glucose
metabolism in tumors are associated with a poor
prognosis in patients with oral squamous cell carcinoma
/ M. Kunkel [et al.] // Cancer. – 2003. – Vol. 97. – P. 10151024.
6. Ʉɪɷɛɬɪɢ, Ȼ. Ɍɟɪɦɨɞɢɧɚɦɢɤɚ ɢ ɨɛɦɟɧ ɜɟɳɟɫɬɜ / Ȼ.
Ʉɪɷɛɬɪɢ, Ⱦ. Ɍɟɣɥɨɪ // Ȼɢɨɯɢɦɢɱɟɫɤɚɹ ɬɟɪɦɨɞɢɧɚɦɢɤɚ. – Ɇ.: Ɇɢɪ, 1982. – ɋ. 372-427.
7. Howell, B. F. Lactate-to- pyruvate of pyruvate-tolactate assay for lactate dehydrogenase: a reexamination / B. F. Howell, S. Mc Cune, R. Schaffer //
Clin. Chem. – 1979. – Vol. 25, N 2. – P. 269-272.
8. ɓɟɤɥɢɤ, ɗ. Ʉɥɢɧɢɱɟɫɤɚɹ ɮɟɪɦɟɧɬɨɥɨɝɢɹ / ɩɨɞ ɪɟɞ.
ɗ. ɓɟɤɥɢɤɚ. – ȼɚɪɲɚɜɚ.: ɉɨɥɶɫɤɨɟ ɝɨɫɭɞɚɪɫɬɜɟɧɧɨɟ
ɦɟɞɢɰɢɧɫɤɨɟ ɢɡɞɚɬɟɥɶɫɬɜɨ, 1966. – 491 ɫ.
ɉɨɫɬɭɩɢɥɚ 26.01.2008 ɝ.
95