Christopher B. Wilson Tobias R. Kollmann – , , , , B T- [1]. ( ) , , , 3]. , 4–5 B T, , ( . 1). T- T- BB- 2 . 1. T- a 5 (a) T- 2 (b) T- . B- Ig (PAMPs) T- b , TLRs , T- APRIL, , APCs, . , T, Ig ( ). 36 , (Th) CD4, B- BAFF . APRIL, Y) T- , BAFF (APCs) APCs. B- Ig ( CD40 5 [2, / T- 2 . 5 2. TCD4 . (TCR, CD8 TY) (DCs). DCs TLRs, CD28 (PAMPs) CD80 T- CD86 , ( ). , , , T- , , CTL, DCs, IFN-7. ). Th17, Th2 CD8 T- Th1 , . CD4 T, , ( 37 , CD4 T- , , T, Th2 ( . 2) [2–4]. (DCs) , IL-12p70 , I , CD4 Th1 T- , , . , , , . DCs , . , Th1 CD4 T, . , . , , , . 38